암포탈라이드 C화학적 특성, 용도, 생산
Originator
Amphotalide,ZYF Pharm Chemical
Manufacturing Process
A mixture of 5-phthalimidopentyl bromide (Drake and Garman, J.Amer. Chem.
Sec, 1949, 71, 2426) (296.0 g) and potassium p-nitrophenoxide (177.0 g) in
ethanol (1.5 L) was stirred mechanically, boiled under reflux for 20 h,
concentrated to half its volume, cooled and filtered. The product was washed
with water, dried and crystallised from acetone, giving 1-p-nitrophenoxy-5-
phthalimidopentane, melting point 123°-124°C.
The foregoing 1-p-nitrophenoxy-5-phthalimidopentane (100.0 g) in ethanol (1
L) was reduced by hydrogen over 2% of platinum oxide at 74°C/73 lb. per sq.
in. The filtered solution on cooling gave L-p-aminophenoxy-5-phthalimidopentane, melting point 111°-112° C (recrystallisation from
ethanol).
Therapeutic Function
Antischistosomal
암포탈라이드 준비 용품 및 원자재
원자재
준비 용품
