Calcitonin salmon

Calcitonin salmon 구조식 이미지
카스 번호:
47931-85-1
상품명:
Calcitonin salmon
동의어(영문):
tz-ct;SALMON;calcimar;Salcatonin;Salmotonin;Calcitoran;cibacalcin;Salcitonin;Salmon Calcium;Thyrocalcitonin
CBNumber:
CB2127316
분자식:
C145H240N44O48S2
포뮬러 무게:
3431.85
MOL 파일:
47931-85-1.mol

Calcitonin salmon 속성

녹는점
>222oC (dec.)
밀도
1.54±0.1 g/cm3(Predicted)
저장 조건
−20°C
용해도
0.05 M 아세트산: 1 mg/mL, 투명, 무색
물리적 상태
가루
색상
흰색에서 황백색까지
수용성
1mg/ml로 물에 용해됨
Merck
13,1642
시퀀스
H-[Cys-Ser-Asn-Leu-Ser-Thr-Cys]-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2,(Disulfide bridge: Cys1-Cys7)
InChIKey
IYTKRMFJECGBRF-LXQLIYPUSA-N
CAS 데이터베이스
47931-85-1(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
안전지침서 22-24/25
WGK 독일 3
RTECS 번호 EV8000000
F 고인화성물질 3-10
HS 번호 2937190000
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:

Calcitonin salmon C화학적 특성, 용도, 생산

개요

Calcitonin is a single-chain polypeptide consisting of 32 amino acid residues. Calcitonins as obtained from different species are identical at seven of the first nine residues, contain Gly at position 28, and all terminate with Pro-NH2. The C-terminal proline amide (ProNH2) is very important for the biological function of CT, as is the disulfide bridge between Cys residues at positions 1 and 7. In contrast, the residues from 10 through 27 can be varied and seem to influence CT's potency as well as its duration of action. Salmon CT differs from human CT at 16 amino acid residues.

화학적 성질

White or almost white powder.

용도

Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).

Clinical Use

Only salmon CT is commercially available for medical use, because on a weight basis, it is approximately 45-fold more potent than human CT. Salmon CT, in parenteral form, is approved for treating Paget's disease of bone (generally seen in older persons; involves increased bone resorption and softening of bones), postmenopausal osteoporosis, and hypercalcemia of malignancy (multiple myeloma or advanced breast carcinoma). Salmon CT also is available in a nasal spray formulation, which is used exclusively in the treatment of postmenopausal osteoporosis.

Calcitonin salmon 준비 용품 및 원자재

원자재

준비 용품


Calcitonin salmon 공급 업체

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