쿠코미네A

쿠코미네A
쿠코미네A 구조식 이미지
카스 번호:
75288-96-9
한글명:
쿠코미네A
동의어(한글):
쿠코미네A
상품명:
kukoamine A
동의어(영문):
NSC5398;NSC 5398;NSC-5398;kukoamine A;1,14-Bis(dihydrocaffeoyl)spermidine;N1,N12-Bis(dihydrocaffeoyl) spermine;N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide];N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide];Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-;N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide)
CBNumber:
CB21355400
분자식:
C28H42N4O6
포뮬러 무게:
530.66
MOL 파일:
75288-96-9.mol
MSDS 파일:
SDS

쿠코미네A 속성

끓는 점
872.1±65.0 °C(Predicted)
밀도
1.213±0.06 g/cm3 (20 ºC 760 Torr)
저장 조건
Store at -20°C
용해도
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
물리적 상태
결정성 고체
산도 계수 (pKa)
9.48±0.10(Predicted)
색상
Off-white to yellow
CAS 데이터베이스
75288-96-9

안전

쿠코미네A C화학적 특성, 용도, 생산

개요

Kukoamine A is a spermine alkaloid originally isolated from L. chinense that has diverse biological activities, including anticancer, neuroprotective, and anti-inflammatory properties. Kukoamine A (5-20 μg/ml) inhibits colony formation of U251 and WJ1 glioblastoma cells in a concentration-dependent manner. It halts the cell cycle at the G0/G1 phase and induces apoptosis when used at concentrations of 60 and 80 μg/ml. Kukoamine A (20 and 40 μM) induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury. It increases the number of dopamine neurons in the substantia nigra and striatum, decreases α-synuclein expression, and improves motor function in an MPTP mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg per day. Kukoamine A (10 and 20 mg/kg) decreases IL-1β, TNF-α, and COX-2 protein levels in the hippocampus and increases hippocampal neurogenesis in a rat model of radiation injury. It also selectively inhibits trypanothione reductase (Ki = 1.8 μM), an enzyme that protects certain parasites from oxidative stress, over human glutathione reductase (Ki = >10 mM).

출처

The root bark of Lychium chinense yields this alkaloid. Kukoamine A possesses hypotensive activity inducing hypotension in rats at a dose of 5 mg/kg when given intravenously.

용도

Kukoamine A is a neuroprotective agent which is used to prevent the loss of dopaminergic neurons in substantia nigra.

쿠코미네A 준비 용품 및 원자재

원자재

준비 용품


쿠코미네A 공급 업체

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Shaanxi Pioneer Biotech Co., Ltd .
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Aktin Chemicals, Inc.
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info@aktinchem.com CHINA 1025 58
TargetMol Chemicals Inc.
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support@targetmol.com United States 19973 58

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