스페르미딘
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스페르미딘 속성
- 녹는점
- 23-25 °C
- 끓는 점
- 128-130 °C (14 mmHg)
- 밀도
- 1.00 g/mL at 20 °C
- 굴절률
- n
20/D 1.479(lit.)
- 인화점
- >230 °F
- 저장 조건
- room temp
- 용해도
- H2O: 1 M at 20 °C, 투명, 무색
- 산도 계수 (pKa)
- 10.53±0.19(Predicted)
- 물리적 상태
- 녹은 후에 액체
- 색상
- 무색의
- Specific Gravity
- 0.925
- 수소이온지수(pH)
- 12.0-13.5 (25℃, 1M in H2O)
- 냄새
- 익티알, 암모니아성
- 수용성
- 물, 에탄올, 에테르와 혼합 가능.
- 감도
- Air Sensitive
- 최대 파장(λmax)
- λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.05
- Merck
- 14,8742
- BRN
- 1698591
- 안정성
- 안정적이지만 공기에 민감하고 흡습성이 매우 높으므로 아르곤 상태로 보관하십시오. 산, 산 염화물, 산 무수물, 산화제와 호환되지 않습니다.
- InChIKey
- ATHGHQPFGPMSJY-UHFFFAOYSA-N
- CAS 데이터베이스
- 124-20-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C | ||
---|---|---|---|
위험 카페고리 넘버 | 34 | ||
안전지침서 | 26-36/37/39-45-27 | ||
유엔번호(UN No.) | UN 2735 8/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | EJ7000000 | ||
F 고인화성물질 | 3-10-34 | ||
TSCA | Yes | ||
위험 등급 | 8 | ||
포장분류 | III | ||
HS 번호 | 29212900 | ||
기존화학 물질 | KE-01572 |
스페르미딘 C화학적 특성, 용도, 생산
개요
Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase.화학적 성질
Spermidine solution is a colorless clear liquid with very hygroscopic and oxidizable. It is soluble in water (50 mg/ml), ethanol, and ether.Source
Spermidine is found in fresh green pepper, wheat germ, cauliflower, broccoli, mushrooms, and a variety of cheeses. Even higher amounts are found in soybean products such as natto, shitake mushrooms, amaranth grain and durian. Some of these ingredients are particularly common in a Mediterranean diet, which may explain why some believe eating like the Spanish can prolong your life.주요 응용
Spermidine serves as a precursor of spermine and essential for both normal and neoplastic tissue growth. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.정의
ChEBI: Spermidine is a triamine that is the 1,5,10-triaza derivative of decane. It is a polyamine that is routinely included in restriction enzyme digestions to improve the cleavage efficacy of the DNA. Spermidine counteracts the inhibitory effects of contaminants coisolated with DNA and consequently permits complete digestion of the DNA at lower enzyme concentrations.제조 방법
The linker resin 2 was used in the synthesis of spermidine. In order to initiate the preparation the 2-nitrossulfonamide was anchored on the resin 2 by reaction in THF under reflux. The resulting resin 3 then reacted with 4-bromobutylphthalimide in acetonitrile in the presence of Cs2CO3 as base, generating the resin 4. Protected spermidine 5 was cleaved from resin 4 after treatment with hydrate hydrazine at room temperature. Spermidine 5 was previously prepared by our group in solution system utilizing Fukuyama's sulfonamide.![Synthesis of spermidine Synthesis of spermidine](/NewsImg/2022-10-03/6380039510946314416019565.jpg)
Synthesis and Characterization of a Linker for Primary Amines used in the Solid Phase Organic Synthesis of Spermidine
J. Braz. Chem. Soc., Vol. 22, No. 1, 86-91, 2011
DOI: 10.1590/S0103-50532011000100011
Origin
Spermidine was first discovered in 1678 by Dutch scientist Anton Van Leeuwenhoek in a sample of human semen. Shortly after, spermidine was discovered in human sperm. In the body, spermidine is created from its precursor putrescine.benefits
The biggest benefit of spermidine is its ability to reduce age-related diseases. It benefits cardioactive, spermidine can reduce the development of atherosclerosis in mice by reducing inflammation and improving cellular (mitochondria) function. It can reduce the formation of blood clots (platelet aggregation) and improve the normal dilation of cells lining blood vessels. Spermidine lowers blood pressure, improves energy use, and reduces heart cell death. It prevents neurologic diseases, and spermidine helps reduce cognitive, memory, and functional impairment associated with aging. It can also Decrease blood sugar levels, Increase autophagy, Increase bone strength, and have Anti-inflammatory effects.Mode of action
Spermidine's main mechanism of action is its ability to induce autophagy, a self-preservation process which clears out toxic, damaged and dysfunctional cells, resulting in lower levels of inflammation in the body. Autophagy is the main mechanism of spermidine in delaying aging and prolonging the lifespan. In addition, spermidine exerts its effects through other mechanisms, including anti-inflammation, histone acetylation reduction, lipid metabolism and regulation of cell growth and signaling pathways.참고 문헌
Madeo, F., Eisenberg, T., Pietrocola, F., et al. Spermidine in health and disease. Science 359(6374), eaan2788 (2018).Lopatin, A.N., Makhina, E.N., and Nichols, C.G. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372(6504), 366-369 (1994).
Eisenberg, T., Knauer, H., Schauer, A., et al. Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 11(11), 1305-1314 (2009).
Guo, X., Harada, C., Namekata, K., et al. Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis. Invest. Ophthalmol. Vis. Sci. 52(5), 2696-2703 (2011).
Eisenberg, T., Abdellatif, M., Schroeder, S., et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat. Med. 22(12), 1428-1438 (2016).
스페르미딘 준비 용품 및 원자재
원자재
수소화나트륨
디 -Tert- 부틸 디 카보네이트
테트라하이드로푸란
수소화 리튬알미늄
3-브로모프로피오니트릴
1,4-디아미노부탄
3-아미노프로판알
스퍼민
N-Ethyl-1,3-propanediamine
3-(Benzylamino)propylamine
벤질아민
준비 용품
스페르미딘 공급 업체
글로벌( 424)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 990 | 58 |
SyncoZymes (Shanghai) Co., Ltd., | +86-021-68187180-811 +86-13681683526 |
lchen@syncozymes.com | China | 188 | 58 |
Maintain Biotech Co., Ltd. | +86-75589664337 +86-15112661142 |
cami@maintain-bio.com | China | 58 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50000 | 58 |
BINBO BIOLOGICAL CO.,LTD | +8618629063126 |
info@binbobiological.com | China | 346 | 58 |
HangZhou RunYan Pharma Technology Co.,LTD. | +86-88660901 +86-18882027439 |
sales2@runyanpharma.com | China | 275 | 58 |
Jinan Jianfeng Chemical Co., Ltd | +8615562555968 |
info@pharmachemm.com | China | 243 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5989 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5867 | 58 |
스페르미딘 관련 검색:
스페르미딘 트리하이드로클로라이드 다이아이소프로필아민 1,4-디아미노부탄 카바민산 암모늄 1,3-디아미노구아니딘 모노하이드로클로라이드 N,N-다이아이소프로필에틸아민 디알릴아민 알릴아민 파라-멘타디엔 스퍼민 스페르미딘
CAO-30
Lithium diisopropylamide
Spermidine-[D8].3HCl
NA
Spermidine-(butane-13C4) trihydrochloride
SPERMINE TETRAHYDROCHLORIDE
Spermidine hexahydrate phosphate salt,SPERMIDINE PHOSPHATE SALT,SPERMIDINE PHOSPHATE