SM 5887
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SM 5887 속성
- 녹는점
- 145-151°
안전
| 독성 | LD50 i.v. in mice: 32-50 mg/kg (Morisada) |
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SM 5887 C화학적 특성, 용도, 생산
개요
small and small-cell lung cancers. Amrubicin, a completely synthetic anthracycline derivative, mediates its growth inhibitory action via topoisomerase II inhibition. It is activated in viva by the formation of its 13-OH metabolite, amrubicinol, via reaction with carbonyl reductase. In contrast to doxorubicin and daunorubicin whose metabolites are inactive in the blood, amrubicinol is 10-100 fold more cytotoxic than amrubicin. In phase II clinical trials, amrubicin showed antitumor activity against non-small-cell lung cancers (response rate exceeding 20%) and against untreated extensive stage small-cell-lung cancers (response rate 78.8%). Amrubicin demonstrated a smaller distribution-volume, a shorter half-life in mice and also less chronic cardiotoxicity in preclinical studies compared to doxorubicin. Amrubicin was generally well tolerated with major adverse events being anaemia, leucopenia, thrombocytopenia and neutropenia.Originator
Sumitomo (Japan)상표명
CalsedSM 5887 준비 용품 및 원자재
원자재
준비 용품
SM 5887 공급 업체
글로벌( 13)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10991 | 58 |
| MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4863 | 58 |
| BOC Sciences | 16314854226 |
info@bocsci.com | United States | 9926 | 65 |
| Musechem | +1-800-259-7612 |
info@musechem.com | United States | 4662 | 60 |
| Shenzhen Botel Biotechnology Co. Ltd. | 0755-22202135 13316968096 |
1979313431@qq.com | China | 8734 | 58 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 |
1461866103@qq.com | China | 16111 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 |
wulan@absin.cn | China | 24734 | 58 |
| Hubei Xinyang Medical Technology Co., Ltd | 15347293736 15347293736 |
2853117764@qq.com | China | 8311 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 |
sales@chemhifuture.com | China | 4679 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 |
cb5@aikonchem.com | China | 10529 | 58 |