ChemicalBook >제품 카탈로그 >VU 0360223

VU 0360223

VU 0360223 구조식 이미지

카스 번호:: 1274859-33-4

상품명:: VU 0360223

동의어(영문):: VU 0360223;3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile;3-fluoro-5-(2-methylbenzo[d]thiazol-5-yl)benzonitrile;Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)-;3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile

CBNumber:: CB22569686

분자식:: C15H9FN2S

포뮬러 무게:: 268.31

MOL 파일:: 1274859-33-4.mol

속성

안전

용도

공급 업체 40

VU 0360223 속성

끓는 점: 434.9±35.0 °C(Predicted)

밀도: 1.35±0.1 g/cm3(Predicted)

저장 조건: Store at RT

용해도: Soluble to 25 mM in DMSO

물리적 상태: 가루

산도 계수 (pKa): 1.10±0.10(Predicted)

안전

VU 0360223 C화학적 특성, 용도, 생산

개요

Glutamate, the major excitatory neurotransmitter in the central nervous system, signals through both ionotropic and metabotropic glutamate receptors. Of the eight metabotropic glutamate receptors (mGlus) discovered thus far, development of inhibitors to mGlu5 has been given significant attention in preclinical models of disease, including pain, anxiety, gastresophageal reflux disease, Parkinson’s associated dyskinesia, and fragile X syndrome, as well as in animal models of drug addiction. VU0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 that demonstrates an IC₅₀ value of 61 nM in a calcium mobilization assay and a K_i value of 477 nM in a radioligand binding assay. A 10 μM concentration of VU0360223 results in a near complete blockade of the glutamate response in cortical astrocytes. A 30 mg/kg dose of VU0360223 in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.

용도

VU 0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 for use in drug addiction treatment.

VU 0360223 준비 용품 및 원자재

원자재

준비 용품

VU 0360223 공급 업체

글로벌( 40)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9805	58
BOC Sciences	--	info@bocsci.com	USA	0	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44807	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8617	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24644	58

VU 0360223 관련 검색:

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