페노티아진
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페노티아진 속성
- 녹는점
- 184 °C
- 끓는 점
- 371 °C(lit.)
- 밀도
- 1.362
- 증기압
- 0.0000647 Pa (20 °C)
- 굴절률
- 1.6353
- 인화점
- 202°C
- 저장 조건
- Store below +30°C.
- 용해도
- 0.127mg/l
- 물리적 상태
- 세분화되거나 구슬 모양
- 산도 계수 (pKa)
- pKa 2.52 (Uncertain)
- 색상
- 노란색
- 수소이온지수(pH)
- 6 (10g/l, H2O, 20℃)(aqueous suspension)
- 수용성
- 2mg/L(25℃)
- 감도
- Light Sensitive
- Merck
- 14,7252
- BRN
- 143237
- 노출 한도
- ACGIH: TWA 5 mg/m3 (Skin)
NIOSH: TWA 5 mg/m3
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제, 강산과 호환되지 않습니다. 빛에 노출되면 변색될 수 있습니다.
- InChIKey
- WJFKNYWRSNBZNX-UHFFFAOYSA-N
- LogP
- 3.78 at 25℃
- CAS 데이터베이스
- 92-84-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,N,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-43-51/53-36/38-40-20/21/22-52/53-48/22-22 | ||
안전지침서 | 26-36-61-36/37/39-29-22-36/37 | ||
OEB | B | ||
OEL | TWA: 5 mg/m3 [skin] | ||
WGK 독일 | 1 | ||
RTECS 번호 | SN5075000 | ||
F 고인화성물질 | 8-23 | ||
자연 발화 온도 | 470 °C | ||
TSCA | Yes | ||
HS 번호 | 29343090 | ||
유해 물질 데이터 | 92-84-2(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: > 2000 mg/kg | ||
기존화학 물질 | KE-28250 |
페노티아진 C화학적 특성, 용도, 생산
개요
Phenothiazine was initially synthesized in 1883 by Bernthsen. It was the basis for the development of other drugs including the phenothiazine class of antipsychotics or neuroleptics. Phenothiazines are the largest class of neuroleptics and include agents such as chlorpromazine, thioridazine, and prochlorperazine. In 1933, a derivative of phenothiazine, promethazine, was synthesized. It was found to have much more significant sedative and antihistaminic effects than previous derivatives of phenothiazine and it was used to induce sedation for surgical patients. After promethazine was developed, a series of agents, including chlorpromazine, was synthesized and tested in France at a military hospital by the French physician Laborit. Laborit found that chlorpromazine induced calm in patients and had other effects that might be useful clinically. Chlorpromazine, known colloquially as ‘Laborit’s drug’ was released into the market in 1953 after a trial published in 1952 showed efficacy in treatment of psychosis in 38 individuals who received daily injections of chlorpromazine. Chlorpromazine is the prototypical drug for the phenothiazine class of antipsychotics. The phenothiazines are classified as low-potency antipsychotics and have more side effects at standard doses than the newer agents used as neuroleptics. For example, they are more anticholinergic and have more extrapyramidal effect than newer agents.화학적 성질
Phenothiazine is a greenish-yellow to greenish-gray crystalline substance. Slight odor and taste.용도
Phenothiazines are neuroleptic agents that affect a variety of receptors including dopaminergic receptor sites. Phenothiazines are used to treat psychosis including schizophrenia; violent, agitated, disturbed behavior; and mania secondary to bipolar disorder. Other uses include treatment of pain, headache, hiccups, acute severe anxiety, idiopathic dystonia, withdrawal, taste disorders, leishmaniasis, acute intermittent porphyria, and alleviation of nausea and vomiting. Phenothiazines allow smoother induction of anesthesia, potentiate anesthetic agents, and treat behavioral symptoms secondary to Alzheimer disease and senile dementia. Some phenothiazines exert an antipruritic effect and are useful for the treatment of neurodermatitis and pruriginous eczema, and relieve psychogenic itching.정의
ChEBI: The 10H-tautomer of phenothiazine.일반 설명
Light green to steel-blue powder. Acquires a greenish-brown tint under exposure to sunlight.공기와 물의 반응
Insoluble in water.반응 프로필
Phenothiazine is slowly decomposed by sunlight. . Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.화재위험
Flash point data for Phenothiazine are not available, but Phenothiazine is probably combustible.Safety Profile
Poison by intravenous route. Moderately toxic to humans by ingestion. Experimental reproductive effects. An insecticide. Large doses, i.e., heavy exposure, may cause hemolytic anemia and toxic degeneration of the liver. Can cause skin irritation and photosensitization. Dangerous; when heated to decomposition or on contact with acid or acid fumes it emits hghly toxic fumes of SOx and NOx.잠재적 노출
Phenothiazine is used as an insecticide; as a base for the manufacture of tranquilizers; as anthelmintic in medicine and veterinary medicine; it is used widely as an intermediate in pharmaceutical manufacture; polymerization inhibitor, antioxidant.환경귀착
Physicochemical PropertiesPhenothiazine has the standard formula S(C6H4)2NH and includes a tricyclic structure that is related to the thiazines. Thiazines are used in the manufacture of synthetic dies.
Chlorpromazine
Chlorpromazine is a white to off-white substance (both the base and the hydrochloride salt) that is a powder or waxy solid as a base and a crystalline powder as the hydrochloride. Chlorpromazine is odorless or has a slightly amine-like odor. It has a melting point of 56–58 °C and in the basic form is practically insoluble in water, soluble in alcohol, and less soluble in chloroform and ether. It is freely soluble in dilute mineral acids. As the hydrochloride salt, chlorpromazine is soluble in water, less soluble in alcohol and chloroform, and insoluble in ether. A 10% aqueous solution has a pH of 3.5–4.5.
운송 방법
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name RequiredPurification Methods
Crystallise it from *benzene, toluene, hexane or Me2CO (charcoal) after boiling for 10minutes under reflux. Filter the crystals off and dry them in an oven at 100o, then in a vacuum desiccator over paraffin chips. Also recrystallise it twice from water and dry it in an oven at 100o for 8-10hours. It sublimes at 130o/1mm and has UV with at 253nm in heptane. [Beilstein비 호환성
Organosulfides are incompatible with strong acids and acid fumes; elevated temperatures; sulfur oxides and nitrogen oxides can be produced. Contact with strong reducing agents such as hydrides; azo and diazo compounds, halocarbons, isocyanates can generate heat and may form explosive hydrogen gas폐기물 처리
Dissolve in combustible solvent and spray into incinerator equipped with afterburner and scrubber. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.페노티아진 준비 용품 및 원자재
원자재
준비 용품
페노티아진 공급 업체
글로벌( 605)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12837 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5858 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 973 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 |
admin@hbsaisier.cn | China | 1015 | 58 |
Hebei Longbang Technology Co., LTD | +86-18633929156 +86-18633929156 |
admin@hblongbang.com | China | 941 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21639 | 55 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 |
FandaChem@Gmail.com | China | 9220 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2986 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
페노티아진 관련 검색:
디페닐아민 톨루이딘 BLUE O 메틸렌 블루, 트리수화물 2-메톡시페노티아진 페노티아진 안트라센 프로메타진 수화염화물 클로르프로마진 수화염화물
PROMETHAZINE
Sodium thioglycolate
Ammonium thioglycolate
1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride
ISOPROMETHAZINE HYDROCHLORIDE
PROMETHAZINE SULFOXIDE
rac N-Demethyl Promethazine Hydrochloride
OXOMEMAZINE
10-(1-methylpyrrolidin-3-ylmethyl)phenothiazine
cyano-3((hydroxy-4piperidyl-1)-3propyl)-10phenothiazin