페노티아진

페노티아진
페노티아진 구조식 이미지
카스 번호:
92-84-2
한글명:
페노티아진
동의어(한글):
페노티아진;티오디페닐아민;페노티아진및그화합물;10H-페노티아진;10H-페놀싸이아진;다이벤조-1,4-싸이아진;다이벤조-1,4-티아진;다이벤조싸이아진;다이벤조티아진;싸이오다이페닐아민;티오다이페닐아민;페놀싸이아진
상품명:
Phenothiazine
동의어(영문):
10H-Phenothiazine;THIODIPHENYLAMINE;XL-50;ent38;Feeno;Biverm;ENT 38;Orimon;Reconox;PHENOXUR
CBNumber:
CB2272320
분자식:
C12H9NS
포뮬러 무게:
199.27
MOL 파일:
92-84-2.mol
MSDS 파일:
SDS

페노티아진 속성

녹는점
184 °C
끓는 점
371 °C(lit.)
밀도
1.362
증기압
0.0000647 Pa (20 °C)
굴절률
1.6353
인화점
202°C
저장 조건
Store below +30°C.
용해도
0.127mg/l
물리적 상태
세분화되거나 구슬 모양
산도 계수 (pKa)
pKa 2.52 (Uncertain)
색상
노란색
수소이온지수(pH)
6 (10g/l, H2O, 20℃)(aqueous suspension)
수용성
2mg/L(25℃)
감도
Light Sensitive
Merck
14,7252
BRN
143237
노출 한도
ACGIH: TWA 5 mg/m3 (Skin)
NIOSH: TWA 5 mg/m3
안정성
안정적인. 타기 쉬운. 강한 산화제, 강산과 호환되지 않습니다. 빛에 노출되면 변색될 수 있습니다.
InChIKey
WJFKNYWRSNBZNX-UHFFFAOYSA-N
LogP
3.78 at 25℃
CAS 데이터베이스
92-84-2(CAS DataBase Reference)
NIST
Phenothiazine(92-84-2)
EPA
Phenothiazine (92-84-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi,N,Xn
위험 카페고리 넘버 36/37/38-43-51/53-36/38-40-20/21/22-52/53-48/22-22
안전지침서 26-36-61-36/37/39-29-22-36/37
OEB B
OEL TWA: 5 mg/m3 [skin]
WGK 독일 1
RTECS 번호 SN5075000
F 고인화성물질 8-23
자연 발화 온도 470 °C
TSCA Yes
HS 번호 29343090
유해 물질 데이터 92-84-2(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 2000 mg/kg
기존화학 물질 KE-28250
그림문자(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H373 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음 특정 표적장기 독성 - 반복 노출 구분 2 경고 P260, P314, P501
H410 장기적 영향에 의해 수생생물에 매우 유독함 수생 환경유해성 물질 - 만성 구분 1 경고 GHS hazard pictograms P273, P391, P501
예방조치문구:
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P314 불편함을 느끼면 의학적인 조치·조언을 구하시오.
NFPA 704
2
2 0

페노티아진 MSDS


Dibenzo-1,4-thiazine

페노티아진 C화학적 특성, 용도, 생산

개요

Phenothiazine was initially synthesized in 1883 by Bernthsen. It was the basis for the development of other drugs including the phenothiazine class of antipsychotics or neuroleptics. Phenothiazines are the largest class of neuroleptics and include agents such as chlorpromazine, thioridazine, and prochlorperazine. In 1933, a derivative of phenothiazine, promethazine, was synthesized. It was found to have much more significant sedative and antihistaminic effects than previous derivatives of phenothiazine and it was used to induce sedation for surgical patients. After promethazine was developed, a series of agents, including chlorpromazine, was synthesized and tested in France at a military hospital by the French physician Laborit. Laborit found that chlorpromazine induced calm in patients and had other effects that might be useful clinically. Chlorpromazine, known colloquially as ‘Laborit’s drug’ was released into the market in 1953 after a trial published in 1952 showed efficacy in treatment of psychosis in 38 individuals who received daily injections of chlorpromazine. Chlorpromazine is the prototypical drug for the phenothiazine class of antipsychotics. The phenothiazines are classified as low-potency antipsychotics and have more side effects at standard doses than the newer agents used as neuroleptics. For example, they are more anticholinergic and have more extrapyramidal effect than newer agents.

화학적 성질

Phenothiazine is a greenish-yellow to greenish-gray crystalline substance. Slight odor and taste.

용도

Phenothiazines are neuroleptic agents that affect a variety of receptors including dopaminergic receptor sites. Phenothiazines are used to treat psychosis including schizophrenia; violent, agitated, disturbed behavior; and mania secondary to bipolar disorder. Other uses include treatment of pain, headache, hiccups, acute severe anxiety, idiopathic dystonia, withdrawal, taste disorders, leishmaniasis, acute intermittent porphyria, and alleviation of nausea and vomiting. Phenothiazines allow smoother induction of anesthesia, potentiate anesthetic agents, and treat behavioral symptoms secondary to Alzheimer disease and senile dementia. Some phenothiazines exert an antipruritic effect and are useful for the treatment of neurodermatitis and pruriginous eczema, and relieve psychogenic itching.

정의

ChEBI: The 10H-tautomer of phenothiazine.

일반 설명

Light green to steel-blue powder. Acquires a greenish-brown tint under exposure to sunlight.

공기와 물의 반응

Insoluble in water.

반응 프로필

Phenothiazine is slowly decomposed by sunlight. . Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

화재위험

Flash point data for Phenothiazine are not available, but Phenothiazine is probably combustible.

Safety Profile

Poison by intravenous route. Moderately toxic to humans by ingestion. Experimental reproductive effects. An insecticide. Large doses, i.e., heavy exposure, may cause hemolytic anemia and toxic degeneration of the liver. Can cause skin irritation and photosensitization. Dangerous; when heated to decomposition or on contact with acid or acid fumes it emits hghly toxic fumes of SOx and NOx.

잠재적 노출

Phenothiazine is used as an insecticide; as a base for the manufacture of tranquilizers; as anthelmintic in medicine and veterinary medicine; it is used widely as an intermediate in pharmaceutical manufacture; polymerization inhibitor, antioxidant.

환경귀착

Physicochemical Properties
Phenothiazine has the standard formula S(C6H4)2NH and includes a tricyclic structure that is related to the thiazines. Thiazines are used in the manufacture of synthetic dies.
Chlorpromazine
Chlorpromazine is a white to off-white substance (both the base and the hydrochloride salt) that is a powder or waxy solid as a base and a crystalline powder as the hydrochloride. Chlorpromazine is odorless or has a slightly amine-like odor. It has a melting point of 56–58 °C and in the basic form is practically insoluble in water, soluble in alcohol, and less soluble in chloroform and ether. It is freely soluble in dilute mineral acids. As the hydrochloride salt, chlorpromazine is soluble in water, less soluble in alcohol and chloroform, and insoluble in ether. A 10% aqueous solution has a pH of 3.5–4.5.

운송 방법

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Purification Methods

Crystallise it from *benzene, toluene, hexane or Me2CO (charcoal) after boiling for 10minutes under reflux. Filter the crystals off and dry them in an oven at 100o, then in a vacuum desiccator over paraffin chips. Also recrystallise it twice from water and dry it in an oven at 100o for 8-10hours. It sublimes at 130o/1mm and has UV with at 253nm in heptane. [Beilstein

비 호환성

Organosulfides are incompatible with strong acids and acid fumes; elevated temperatures; sulfur oxides and nitrogen oxides can be produced. Contact with strong reducing agents such as hydrides; azo and diazo compounds, halocarbons, isocyanates can generate heat and may form explosive hydrogen gas

폐기물 처리

Dissolve in combustible solvent and spray into incinerator equipped with afterburner and scrubber. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

페노티아진 준비 용품 및 원자재

원자재

준비 용품


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