2,6-Dibromopyridine
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2,6-Dibromopyridine 속성
- 녹는점
- 117-119 °C (lit.)
- 끓는 점
- 255°C
- 밀도
- 2.0383 (rough estimate)
- 굴절률
- 1.5800 (estimate)
- 인화점
- 213 °C
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- -3.65±0.10(Predicted)
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 회색 또는 담황색
- 수용성
- 불용성
- BRN
- 108922
- InChI
- InChI=1S/C5H3Br2N/c6-4-2-1-3-5(7)8-4/h1-3H
- InChIKey
- FEYDZHNIIMENOB-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC(Br)=CC=C1
- CAS 데이터베이스
- 626-05-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,T,T+ | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-25-20/21-52-28-52/53-36/38 | ||
안전지침서 | 26-37/39-45-36/37/39-36-36/37-28-61 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | US7883000 | ||
위험 참고 사항 | Irritant | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29333999 |
2,6-Dibromopyridine C화학적 특성, 용도, 생산
화학적 성질
White to light yellow crystalline powder용도
2,6-Dibromopyridine is used as a tridentate chelating ligand and in the formation of macrocycles containing the terpyridine moiety. It is also used to produce 6-bromo-2-methoxypyridine.주요 응용
2,6-Dibromopyridine is an important organic chemical reagent with a wide range of uses:(1) Spectroscopic studies: There is a satisfactory correlation between the normal Raman spectra of 2,6-dibromopyridine in aqueous solution and the surface enhanced Raman (SER) spectra in silver-pure sols. In the SER spectra, the compounds are notable for the stretching of the vibrational modes of (py)CBr and (CC,CN)(py) in 2,6-dibromopyridine to give enhanced vibrational intensities at 1175 and 1369 cm-1 , respectively[1].
(2) Reaction reagent: Friedel–Crafts-type acylation of alkenes with acyl chlorides has been successfully conducted with a wide substrate scope by the combined use of AlCl3 and 2,6-dibromopyridine. Trisubstituted alkenes afford allylketones or vinylketones depending on the presence or absence of hydrogen atom(s) at the β-position to the acylation site, while monosubstituted alkenes exclusively afford vinylketones[2]. In addition, 2,6-Dibromopyridine can be brominated to form 2,4,6-tribromopyridine by reacting with a mixture of bromine at 450~ 550 °C[3]. It can also be lithiated with butyl lithium for the synthesis of L-739,010[4].
(3) A selective palladium-catalysed arylation of 2,6-dibromopyridine has been developed by employing N-heterocyclic carbene ligands. Selective mono-arylation was performed in water/acetonitrile solvent system at ambient temperature with catalyst loading of 0.1 mol%. This reaction was also found to proceed smoothly in water although at a slightly elevated temperature of 80 °C. 2,6-Disubstituted and diversely substituted 2,6-pyridines were also obtained in high yields which will be of importance to organic and medicinal chemists[5].
Purification Methods
Purify 2,6-dibromopyridine by steam distillation, then recrystallise it twice from EtOH. It does not form an HgCl2 salt. [den Hertog & Wibaut Recl Trav Chim Pays Bas 51 381 1932, Beilstein 20/5 V 435.]2,6-Dibromopyridine 준비 용품 및 원자재
원자재
2,3,4,5,6-PENTABROMOPYRIDINE
6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
2,6-디브로모피리딘옥사이드
3-아미노피리딘
2,6-Dibromopyridin-3-amine
2,6-디클로로피리딘
준비 용품
2-Bromo-6-methoxypyridine
6-Methoxypyridine-2-carbaldehyde
2-BROMO-6-(1H-PYRAZOL-1-YL)PYRIDINE
(6-BROMO-2-PYRIDINYL)-카르밤산,1,1-디메틸에틸에스테르
2-Amino-6-bromopyridine
6-에톡시-2-피리디나민
6-Bromopyridine-2-carbaldehyde
6-TERT-BUTOXYPYRIDINE-2-CARBOXALDEHYDE
2-Amino-6-methoxypyridine
아크리바스틴
2,6-Dihydroxypyridine
4-AMINO-2,6-DIBROMOPYRIDINE
2,6-DIETHYNYLPYRIDINE
2,6-Dibromopyridine 공급 업체
글로벌( 602)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Changzhou Jiuwu Chemical co., Ltd. | +86-0519-85121086 +8613775162768 |
info@jiuwuchem.cn | China | 75 | 58 |
Taizhou Creating Bio-pharm co., ltd. | +8613586099526 |
post@creatingbiopharm.com | China | 217 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21673 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +8615064153060 |
sales01@jndxj.com | China | 293 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10318 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
2,6-Dibromopyridine 관련 검색:
브롬
2,6-Dibromopyridine
2,6-Dibromopyridine oxide
3-Amino-2,6-dibromopyridine ,98%
2,6-Dibromo-3-nitropyridine
1,3-DIBROMOISOQUINOLINE
2,4,6-Tribromopyridine
2,5-DIBROMOPYRIDINE-3-BORONIC ACID
3,5-DIBROMOPYRIDINE
2,3-DIBROMOPYRIDINE,2,3-DIBROMOPYRIDINE 98%
2,6-Dibromopyridine-4-carboxylic acid
3,5-DIBROMOPYRIDINE 1-OXIDE,3,5-DIBROMOPYRIDINE-PYRIDIN 1-OXIDE, 98+%
4-Methyl-3,5-dibromopyridine
3,5-DIBROMO-2-FLUOROPYRIDINE/2-FLUORO-3,5-DIBROMOPYRIDINE
3,5-Dibromopyridine-2(1H)-one
3,5-DIBROMOPYRIDINE-2-CARBOXYLIC ACID
3,5-Dibromopyridine-4-carboxaldehyde
3,4-DIBROMOPYRIDINE