Nabumetone
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Nabumetone 속성
- 녹는점
- 80-810C
- 끓는 점
- 330.1°C (rough estimate)
- 밀도
- 1.0657 (rough estimate)
- 굴절률
- 1.5542 (estimate)
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- 알코올이나 클로로포름에 용해됨
- 물리적 상태
- Solid
- 색상
- 하얀색
- 수용성
- 6mg/L(22.5℃)
- BCS Class
- 2/4
- CAS 데이터베이스
- 42924-53-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): | |||||||||||||||
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Nabumetone C화학적 특성, 용도, 생산
개요
Nabumetone is a non-acidic, nonsteroidal antiinflammatory agent formally related to naproxen. Its main circulating metabolite is 6-methoxy-2-naphthylacetic acid (α-nornaproxen). Administered once daily (Tsub>1/2 * 30 hrs), nabumetone is reported to be effective in the treatment of rheumatoid and osteoarthritis.화학적 성질
White Powder용도
Nabumetone is an anti-inflammatory and antibacterial agent (1). A non-steroidal anti-inflammatory prodrug used for treatment of inflammatory and degenerative rheumatic diseases.Indications
Nabumetone (Relafen) is approved for rheumatoid arthritis, osteoarthritis, and pain management. Its long half-life allows for once-daily dosing. Although this drug is a weak inhibitor of COX, it is metabolized in the liver to 6-methoxy-2-naphthylacetic acid (6-MNA), a strong COX inhibitor that is chemically similar to naproxen. As with most NSAIDs, GI side effects are most commonly reported. The incidence of gastric ulceration is lower with nabumetone than with many other NSAIDs.This is due to its nature as a prodrug, not to COX-2 selectivity. Lower-bowel complaints, rashes, and CNS disturbances are common adverse effects.정의
ChEBI: A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is s own to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.일반 설명
Nabumetone (Relafen), a nonacidic NSAID prodrug, isclassified as an arylacetic acid, because it undergoes rapidhepatic metabolism to its active metabolite, 6-methoxy-2-naphthylacetic acid. Similar to the other arylacetic aciddrugs, it is used in short- or long-term management of RAand OA. Being nonacidic, it does not produce significantprimary insult to the GI mucosa lining and also has no effecton prostaglandin synthesis in gastric mucosa, thus producingminimum secondary GI damage when comparedwith other conventional NSAIDs.Pharmacokinetics
Nabumetone is absorbed primarily from the duodenum. Milk and food increase the rate of absorption and the bioavailability of the active metabolite. Plasma concentrations of unchanged drug are too low to be detected in most subjects after oral administration, so most pharmacokinetic studies have involved the disposition of the active metabolite. Pharmacokinetic properties are altered in elderly patients, with higher plasma levels of the active metabolite being noted. Nabumetone undergoes rapid and extensive metabolism in the liver, with a mean absolute bioavailability of the active metabolite of 38%. The metabolism of nabumetone is illustrated in Figure 36.15. The major, most active metabolite is 6MNA, but the initial alcohol metabolite, a minor product, and its esters also possess significant anti-inflammatory properties.Clinical Use
Nabumetone is indicated for the acute and chronic treatment of the signs and symptoms of osteoarthritis and rheumatoid arthritis. The recommended starting dosage is 1,000 mg as a single dose with or without food. More symptomatic relief of severe or persistent symp-toms may be obtained at doses of 1,500 or 2,000 mg/dayNabumetone 준비 용품 및 원자재
원자재
하이드라진 수화물
아세트산 제II구리, 무수
질소
에틸알코올
염화칼슘
염화나트륨
아세틸 염화물
나트륨
구리 아세트산 모노수화물
클로로포름
나트륨 에톡시드
염화알루미늄
클로로술폰산
수소
디메틸설페이트
메틸산 나트륨
중아황산나트륨
2-아세틸-5-브로모-6-메톡시나프탈렌
Palladium hydroxide
아세트산 나트륨
준비 용품
Nabumetone 공급 업체
글로벌( 276)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12490 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
sales@suikangpharm.com | China | 311 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21665 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8820 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Nabumetone 관련 검색:
아니졸 메톡시아세트 산 P-아니시딘 트리플르오르메톡시벤젠 나프탈렌 2-브로모-6-메톡시나프탈렌 메틸에틸케톤
m-Anisyl alcohol
NABUMETONE IMPURITY F
NABUMETONE IMPURITY D
D-EQUILENIN ACETATE
1,3-Butanedione, 1-(6-methoxy-2-naphthalenyl)-
D-1,3,5(10), 6,8-ESTRAPENTAEN-3-OL-17-ONE BENZYL ETHER
viridicatumtoxin
D-1,3,5(10), 6,8-ESTRAPENTAEN-3-OL-17-ONE ETHYL ETHER
D-1,3,5(10), 6,8-ESTRAPENTAEN-3-OL-17-ONE BENZOATE
D-1,3,5(10), 6,8-ESTRAPENTAEN-3-OL-17-ONE METHYL ETHER
NABUMETONE RELATED COMPOUND A (15 MG) (1-(6-METHOXY-2-NAPHTHYL)-BUT-1-EN-3-ONE)