EveroliMus-d4
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EveroliMus-d4 속성
- 저장 조건
- Store at 4°C
- 용해도
- Chloroform: Soluble,Methanol: Soluble
- 물리적 상태
- 고체
- 색상
- White to off-white
- 안정성
- 흡습성
- 주요 응용
- 임상 시험
- InChIKey
- HKVAMNSJSFKALM-ULVVDLMCSA-N
- SMILES
- [2H]C([2H])(O)C([2H])([2H])OC1CCC(CC(C)C2CC(=O)C(C)\C=C(C)\C(O)C(OC)C(=O)C(C)CC(C)\C=C\C=C\C=C(C)\C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC)CC1OC
- CAS Number Unlabeled
- 159351-69-6
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | WGK 2 | ||
|---|---|---|---|
| 스토리지 클래스 | 3 - Flammable liquids | ||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 |
| 그림문자(GHS): |
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| 신호 어: | Danger | ||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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EveroliMus-d4 C화학적 특성, 용도, 생산
개요
Everolimus-d4 is intended for use as an internal standard for the quantification of everolimus by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation.일반 설명
A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress and Certican for use in organ transplantation and Afinitor for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.EveroliMus-d4 준비 용품 및 원자재
원자재
준비 용품
EveroliMus-d4 공급 업체
글로벌( 54)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 |
shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 |
anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Cato Research Chemicals Inc. | 020-81960175 |
min.he@cato-chem.com | China | 1949 | 55 |
| Artis Biotech Co. Ltd. | 18108108965 18108108965 |
sales@artisbio.com | China | 2505 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 |
yanzihan@shyuanye.com | China | 87240 | 60 |
| Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 17361806303 |
kexin.zhou@haolvbiotech.com | China | 3009 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 |
sales@rrkchem.com | China | 57336 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 |
983438788@qq.com | China | 2472 | 58 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 020-36607679; 13502246435 |
3008233746@qq.com | China | 9959 | 12 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14320 | 58 |
EveroliMus-d4 관련 검색:
비스(T-부틸디메틸실록시)에탄
Everolimus Impurity 1
2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone
Everolimus Ring-Opening Impurity
Everolimus
Everolimus Related Compound 3
EveroliMus iMpurity
Everolimus O-Ethyl Impurity
2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
Everolimus Related Compound 2
Ethyleneglycol bistriflate
Methanesulfonic acid, trifluoro-, 2-hydroxyethyl ester
28-epirapamycin
Everolimus Hydrolized Impurity
Seco Rapamycin
Rapamycin, 32-O-demethyl-
23,27-Epoxy(7E,15E,17E,19E)-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexam...
USDOYNAPNXMXOE-SPSCNLKESA-N