Vecuronium bromide
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Vecuronium bromide 속성
- 녹는점
- 227-229°C
- 알파
- +30.5~+35.0゜(D/20℃)(c=0.5,dil.HCl)
- 저장 조건
- Inert atmosphere,Store in freezer, under -20°C
- 용해도
- 물에 약간 용해되고 염화메틸렌에 쉽게 용해되며 아세토니트릴 및 무수 에탄올에 조금 용해됩니다.
- 물리적 상태
- Solid
- 색상
- 하얀색
- Merck
- 14,9941
- BRN
- 4837308
- 안정성
- 흡습성
- InChIKey
- VEPSYABRBFXYIB-PWXDFCLTSA-M
- CAS 데이터베이스
- 50700-72-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-22 | ||
안전지침서 | 26-37/39 | ||
WGK 독일 | 3 | ||
RTECS 번호 | TN4875000 | ||
HS 번호 | 2933399090 | ||
독성 | LD50 in mice: 0.061 mg/kg i.v. (Buckett) |
Vecuronium bromide MSDS
(+)-1-(3,17-Diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium bromide
Vecuronium bromide C화학적 특성, 용도, 생산
개요
Vecuronium, 1-[(2β,3α,5α,16β,17β,)-3,17-bis(acetyloxy)-2-(1-piperidinyl) androstan-16-yl]-1-methylpiperidinium bromide (15.1.9), differs from panuronium only in the extent of alkylation. Only the piperidine substituent on C16 of the steroid skeleton is transformed into a quaternary salt.화학적 성질
White Solid용도
An aminosteroid, competitive neuromuscular blocker agent.정의
ChEBI: The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium su stituents.Biological Functions
Vecuronium bromide (Norcuron) is chemically identical to pancuronium except for a tertiary amine in place of a quaternary nitrogen. However, some of the drug will exist as the bisquaternary compound, depending on body pH. Vecuronium has a moderate onset of action (2.4 minutes) and a duration of effect of about 50 minutes. Like pancuronium, it does not block ganglia or vagal neuroeffector junctions, does not release histamine, and is eliminated by urinary excretion.일반 설명
Vecuronium bromide, 1-(3 ,17 -dihydroxy-2 -piperidino-5 -androstan-16 -yl)-1-methylpiperidinium bromide diacetate (Norcuron), is themonoquaternary analog of pancuronium bromide. It belongsto the class of nondepolarizing neuromuscular blockingagents and produces effects similar to those of drugs in thisclass. It is unstable in the presence of acids and undergoesgradual hydrolysis of its ester functions in aqueous solution.Aqueous solutions have a pH of about 4.0.Mechanism of action
Vecuronium bromide is a bisquaternary nitrogen compound that acts by competitively binding to nicotinic cholinergic receptors. The binding of vecuronium decreases the opportunity for acetylcholine to bind to the nicotinic receptor at the postjunctional membrane of the myoneural junction. As a result, depolarization is prevented, calcium ions are not released and muscle contraction does not occur.Pharmacology
Vecuronium bromide is steroidal agent that was developed in an attempt to reduce the cardiovascular effects of pancuronium. I t is similar in structure to the older drug, differing only in the loss of a methyl group from one quaternary ammonium radical. Thus it is a monoquaternary amine. An intubating dose of 0.1mgkg-1 produces profound neuromuscular block within 3min. This dose produces clinical block for about 30min. Vecuronium rarely produces histamine release, nor does it have any direct cardiovascular effects, although it allows the cardiac effects of other anaesthetic agents, such as bradycardia produced by the opioids, to go unchallenged. Vecuronium is excreted through the kidneys (30%), although to a lesser extent than pancuronium, and undergoes hepatic deacetylation; the deacetylated metabolites have neuromuscular blocking properties. Repeated doses should be used with care in patients with renal or hepatic disease because they accumulate.Clinical Use
Vecuronium Bromide is usedmainly to produce skeletal muscle relaxation during surgeryand to assist in controlled respiration after general anesthesiahas been induced.Vecuronium bromide 준비 용품 및 원자재
원자재
준비 용품
Vecuronium bromide 공급 업체
글로벌( 455)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Beijing Mesochem Technology Co.,Ltd | +8613651027935 |
rachel@mesochem.com | China | 191 | 58 |
S&Y Biochem Co.,Ltd | +8617774091612 |
marketing@sybiochem.com | China | 109 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12495 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8820 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
Vecuronium bromide 관련 검색:
브로민산나트륨 에티듐 브로마이드 브롬화알릴 판쿠로늄 브롬화물 브롬화 메틸
Rocuronium bromide
Iodixanol
Vecuronium for system suitability
VECURONIUM FOR PEAK IDENTIFICATION
VECURONIUM BROMIDE RELATED COMPOUND A (25 MG) (3ALPHA, 17BETA-DIACETYL-OXY-2BETA, 16BETA-BISPIPERIDINYL-5ALPHA-ANDROSTAN)
Rapacuronium
Vecuronium bromide
VBMC inter.for 7AVC,Cefixime cefdinir
17 beta-(O-propionyl)-vecuronium bromide
Vecuronium Bromide for Injection
17 beta-(O-butyryl)-vecuronium bromide
VECURONIUM BROMIDE''S INTERMEDIATES
VBMC