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K-252B

K-252B 구조식 이미지

카스 번호:: 99570-78-2

상품명:: K-252B

동의어(영문):: K-252B;KT 5556;k-252b solution;K252B READY MADE;Antibiotic K 252b;K-252B, NOCARDIOPSIS SP;K-252B, NOCARDIOPSIS SPECIES;PROTEIN KINASE INHIBITOR K-252B;K252b Antibiotic K 252b KT 5556;(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid

CBNumber:: CB3452783

분자식:: C26H19N3O5

포뮬러 무게:: 453.45

MOL 파일:: 99570-78-2.mol

속성

안전

용도

공급 업체 104

K-252B 속성

끓는 점: 769.8±60.0 °C(Predicted)

밀도: 1.78±0.1 g/cm3(Predicted)

저장 조건: −20°C

용해도: DMSO(최대 1mg/ml) 또는 DMF(최대 1mg/ml)에 용해됩니다.

물리적 상태: 액상

산도 계수 (pKa): 3.33±0.40(Predicted)

색상: 흰색 또는 황백색

안정성: 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 DMF의 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.

안전

위험품 표기	Xi
유엔번호(UN No.)	UN 1993 / PGIII
HS 번호	29349990

K-252B C화학적 특성, 용도, 생산

개요

K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-mediated degranulation from basophil-like RBL-2H3 cells (IC₅₀ = 0.5 μg/ml) and human basophils. This extracellular inhibitor is also used in comparison studies with the closely related, cell-permeable inhibitor K252a, particularly in studies of neuronal differentiation.

화학적 성질

Yellow solid

용도

K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).

K-252B 준비 용품 및 원자재

원자재

준비 용품

K-252B 공급 업체

글로벌( 104)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 13675144456	sean.lv@synzest.com	China	11442	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-400-6206333 18521732826	market@aladdin-e.com	China	25013	65
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7855	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58

K-252B 관련 검색:

설파마이드 질산칼륨 AKOS 213-252 Amberlite 252, Ion Exchange Resin HC-252 9-CARBAZOLEPROPIONIC ACID KT5720 1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97 9-ISOPROPYLCARBAZOLE 1,3,5,7,9-Pentaoxa-252, 452,652,852-tetraplumbacyclotridec-11 -ene-10,13-dione, (Z)- C.I. Acid Red 252 PROTEIN KINASE INHIBITOR K-252A FROM NOCARDIOPSIS SP.) K-252C K-252B CARBAZOL-9-YL-METHANOL 11,12-Dihydroindolo[2,3-a]carbazole Hydrochlorofluorocarbon-252 (HCFC-252) GP120 (252-272) (1)