ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21) C화학적 특성, 용도, 생산
용도
Anti-UCHL1 antibody produced in rabbit has been used in:
immunohistochemistry at 1:100 dilution
immunofluorescence
proximity ligation assay
indirect immunolabeling at 1:1000 dilution
일반 설명
The ubiquitin C-terminal hydrolase L1 (UCH-L1) gene is mapped to human chromosome 4p13. The protein localized in the cytosol and nucleus. UCH-L1 protein is primarily expressed in neuroendocrine tissues, neurons and in testis/ovary. Rabbit polyclonal anti-UCHL1 antibody recognizes ubiquitin carboxyl-terminal hydrolase isozyme L1.
Biochem/physiol Actions
Ubiquitin C-terminal hydrolase-L1 (UCHL1) is a deubiquitinating enzyme (DUB) that hydrolyzes C-terminal ubiquitin esters and amides, and peptide?ubiquitin amides to ubiquitin monomers in- vitro. In addition to DUB activity, it also possesses E3 ubiquitin-protein ligase activity. UCHL1 is involved in the regulation of the ubiquitin-dependent proteolytic system. UCH-L1 plays a vital role in cancer development and progression by upstream activation of protein kinase B (Akt). Mutation in the UCHL1 gene is associated with the development of Parkinson′s disease (PD).
ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21) 준비 용품 및 원자재
원자재
준비 용품
ANTI-UBIQUITIN-C-TERMINAL HYDROLASE L1 (TS-21) 공급 업체
