OXAMFLATIN
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OXAMFLATIN 속성
- 녹는점
- 98-100°C
- 밀도
- 1.44±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 13mg/mL, 가용성
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 7.75±0.10(Predicted)
- 색상
- Light yellow to yellow
- 안정성
- 감광성
안전
| 안전지침서 | 22-24/25 | ||
|---|---|---|---|
| WGK 독일 | 3 |
OXAMFLATIN C화학적 특성, 용도, 생산
화학적 성질
Red-Brown Solid용도
Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.효소 저해제
This anti-tumor agent (FW = 342.38 g/mol; CAS 151720-43-3; Solubility: 13 mg/mL DMSO, methanol, acetonitrile, 10 mg/mL), also known as (2E)- 5-[3-[(phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamate, inhibits histone deacetylase. Oxamflatin shows antiproliferative activity in vitro against various mouse and human tumor cell lines, attended by drastic changes in the cell morphology and in vivo antitumor activity against B16 melanoma. Oxamflatin causes an elongated cell shape with filamentous protrusions as well as arrest of the cell cycle at the G1 phase in HeLa cells. These phenotypic changes in HeLa cells were similar to those induced by trichostatin A (TSA), a specific inhibitor of histone deacetylase (HDAC).OXAMFLATIN 준비 용품 및 원자재
원자재
준비 용품
OXAMFLATIN 공급 업체
글로벌( 55)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9337 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
| Hong Kong Tiansheng New Material Trading Co., Ltd | +8617320695765 |
zxx@hktiansheng.com | China | 981 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 |
sales06@hbduling.cn | China | 8104 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 |
sales@BioChemBest.com | China | 6008 | 61 |