Cepharanthine

Cepharanthine 속성

Cepharanthine MSDS

6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))-oxyacanthan

Cepharanthine C화학적 특성, 용도, 생산

개요

Cepharanthine is diclofenac quinoline alkaloid isolated from rhizome of Stephania japonica, which was first recorded in “Bencao shiyi” and functions as clearing heat, promoting diuresis and detumescence in traditional Chinese medicine. Cepharanthine is a pure and natural extract of the Stephania cepharantha Hayata plant, a rare species that is native to Kotosho Island, southeast of Taiwan. In 1914, the renowned botanist, Bunzo Hayata reported the plant for the first time. Two decades later, Dr. Heisaburo Kondo purified its active ingredient and named it “Cepharanthine.” Stephania japonica was used to treat tuberculosis and other consumptive diseases which provided a clue for its development on lung disease.

물리적 성질

Appearance: light yellow or yellow powder. Solubility: soluble in acidic aqueous solution and ether, acetone, and other organic solvents; insoluble in petroleum ether. Melting point: 148–150°C. Specific optical rotation: +277°.

역사

Promoting leukocytosis of cepharanthine in tuberculosis patients was first recorded in the proceeding Institute of Chemotherapy by the Japanese scholar Yamaguchi in 1946. In 1948, Chinese scholar Yuhuang Zhao also received this compound and published it in D.M.Med.
It is thought that cepharanthine may stimulate the reticuloendothelial system, then activate hematopoietic tissue, and promote myeloproliferation. Therefore, the number of white blood cells in the peripheral blood increased significantly. Due to its good safety, cepharanthine is currently widely used in cancer patients with granulocytopenia or leukopenia embolism after radiotherapy and chemotherapy and so on.
In addition, Chinese scientists extracted five kinds of dibenzylisoquinoline alkaloids from Chinese herbal medicine in 1977, which could significantly improve the silicosis symptoms in rat . In 1993, it was issued as anti-pneumoconiosis drug by CFDA and is used for delaying the progress of pneumoconiosis in clinic.

용도

Cepharanthine is a biscoclaurine alkaloid that has antiinflammatory, antineoplastic, hepatoprotectant, radiopropective and other biological functions. It is used to treat many acute and chronic diseases, including pit viper bites, alopecia areata, and leucopenia in radiation therapy.

정의

ChEBI: Cepharanthine is a bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. It is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.

Pharmacology

The pharmacological effects of cepharanthine are very broad, mainly for the promotion of leukocytosis, antitumor, anti-inflammation, improvement of the body immunity, and other aspects of efficacy. Improvement of leukocytosis is the most widely studied among them, and the mechanism may be to stimulate the reticular endothelium system, activate hematopoietic tissue, and promote bone marrow hyperplasia .
Cepharanthine is also a good antitumor drug sensitizer. It can significantly improve their efficacy and reduce their side effects when combined with other antitumor drugs, as manifested by increasing the concentration of FT-207 metabolite (5-Fu) in tumor tissue under cepharanthine and FT-207 combination therapy, which was significantly higher than that in blood , suggesting that cepharanthine has the potential to improve the efficacy of antitumor drugs.

Clinical Use

The major clinical application of cepharanthine is to improve their immunity impaired by chemotherapy or radiotherapy in tumor patients. In addition, cepharanthine can increase the sensitivity to antitumor drugs, and itself also has a certain antitumor effect. Now, it is commonly used as adjuvant drug for anticancer treatment.

Synthesis

The production of cepharanthine currently relies mainly on natural extraction from the tuberous roots of plants in the genus Stephania (such as Stephania cepharantha Hayata). The process typically involves solvent extraction using ethanol or salt solutions, purification by adsorption with macroporous resins, and recrystallization to obtain a high-purity alkaloid product. Although Tomita et al. achieved its total synthesis as early as 1967, the complex bisbenzylisoquinoline macrocyclic structure of the molecule makes the chemical synthesis steps cumbersome and extremely costly, thus large-scale industrial synthesis and production have not yet been achieved.

Cepharanthine 준비 용품 및 원자재

원자재

준비 용품

Cepharanthine 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Aktin Chemicals, Inc.	028-85159085 18080455027	info@aktin.com	China	2069	58
Wuhan Hongfuda New Materials Co., Ltd.	19107255884 19107255884	2013537414@qq.com	China	494	58
Nanjing bingcheng Biotechnology Co., Ltd.	18805194892	2727751293@qq.com	China	172	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5994	61
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44567	61
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	15343	64
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6717	52
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
Aemon Chemical	0086-755-86198205	acinfo@aemonchem.com	China	1928	57

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