DL-라우다노신
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DL-라우다노신 속성
- 녹는점
- 115°C
- 끓는 점
- 490.07°C (rough estimate)
- 밀도
- 1.1729 (rough estimate)
- 굴절률
- 1.5614 (estimate)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO : 100 mg/mL (279.77 mM)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 7.80±0.40(Predicted)
- 색상
- 흰색~밝은 베이지
- LogP
- 3.630 (est)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
DL-라우다노신 C화학적 특성, 용도, 생산
개요
This opium alkaloid occurs in the liquor following precipitation of Thebaine (q.v.) and is purified by extraction with small quantities of Et20, followed by precipitation with potassium iodide. The base crystallizes from hot C6H6 in small, colourless needles and has [α]15D+ 103.23° (EtOH). It is freely soluble in CHCI3, EtOH, Et20 or hot C6H6 but insoluble in H20 or alkalies. No colour is produced with FeCl 3 but with Fe203 and H2S04, a brown colour is formed, changing to green when warmed to ISOoC. With concentrated H2S04 alone, the alkaloid gives a rose-red colour, changing to deep violet at ISO°C. The solution of the alkaloid in EtOH is alkaline to litmus and both it, and its salts, are bitter to the taste. The crystalline methiodide has m.p. 218-221°C; [α]D + 120°. The oxidation products with Mn02 and H2S04 are veratraldehyde, 2:3:6:7- tetramethoxy-9: I O-dihydroanthracene and laudaline (4: S-dimethoxy-2: - methylaminoethylbenzaldehyde, m.p. 123-4°C. On exhaustive methylation it yields trimethylamine and laudanosene (tetramethoxy-o-vinylstilbene). Laudanosine is one of the most convulsant of the opium alkaloids but possesses only a slight analgesic action.화학적 성질
light yellow fine crystalline powderPurification Methods
Crystallise these from EtOH. The (±)-picrate crystallises from EtOH with m 177-178o. The (-)-isomer has m 83-85o and참고 문헌
Pictet, Athanasescu., Ber., 33, 2347 (1900)Pictet, Finkelstein., ibid, 42, 1979 (1909)
Pyman, Reynolds.,J. Chern. Soc., 97, 1324 (1910)
Kondo, Mori.,J. Ph arm. Soc., Japan, 51,615 (1931)
Craig, Tarbell., J. Amer. Chern. Soc., 70,2783 (1948)
Synthesis:
Pictet, Finkelstein., Compt. rend., 148,925 (1909)
Elliot.,J. Heterocycl. Chern., 7, 1229 (1970)
Pharmacology:
Zunz., Elements de Pharmacodynamie speciale, Tome I, 178, Masson & Co., Paris (1932)
Krueger, Eddy, Sumwalt., U.S. Public Health Reports, Suppl. 165, 1007 (1943)
DL-라우다노신 준비 용품 및 원자재
원자재
준비 용품
DL-라우다노신 공급 업체
글로벌( 82)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Alfa Chemistry | |
Info@alfa-chemistry.com | United States | 24072 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11681 | 58 |
China National Standard Pharmaceutical Corporation Limited | +8615391658522 |
overseasales@yongstandards.com | China | 11927 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
ShenZhen H&D Pharmaceutical Technology Co., LTD | +86-0755-22677845 +86-13627253706 |
sale@hdimpurity.com | China | 3155 | 58 |
Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 |
market03@meryer.com | China | 40240 | 62 |
DL-라우다노신 관련 검색:
Atracurium Impurity 19
PHENYL P-TOLYL SULFONE
Atracurium Impurity 1
Atracurium Impurity 41
Atracurium Impurity 26 Besylate
Cistracurium Besylate EP Impurity D
Atracurium Impurity 18
R-tetrahydropapaverine HCl
1,5-pentanediyl bis[1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-1H-isoquinoline-2-propionate]
AtracuriuM IMpurity V
6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
(1R,2R)-1-[(3,4-Dimethoxyphenyl)methyl]-2-[3-(tert-butoxy)-3-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium benzenesulfonate
Atracurium EP Impurity D
Levonorgestrel Glycidol
DL-LAUDANOSINE
Cepharanthine
DL-laudanosine hydrobromide trihydrate
Atracurium besylate