ChemicalBook >제품 카탈로그 >생화학 공학>억제제>세포주기>CDK 억제제>[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 구조식 이미지

카스 번호:: 741713-40-6

상품명:: [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)

동의어(영문):: R547;CS-238;Ro 4584820;R547(Ro 4584820);R547 >=98% (HPLC);R547 Ro-4584820 R-547;3-difluoro-6-Methoxyphenyl)-;[4-aMino-2-[[1-(Methylsulfonyl)-4-piperidinyl]aMino]-5-pyriMidinyl](2;(4-Amino-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphen;5-[(2,3-difluoro-6-Methoxyphenyl)carbonyl]-2-N-(1-Methanesulfonylpiperidin-4-yl)pyriMidine-2,4-diaMine

CBNumber:: CB41562444

분자식:: C18H21F2N5O4S

포뮬러 무게:: 441.45

MOL 파일:: 741713-40-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 108

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 속성

끓는 점: 703.7±70.0 °C(Predicted)

밀도: 1.49

저장 조건: Store at -20°C

용해도: DMSO에 용해됨

물리적 상태: 결정질 고체

산도 계수 (pKa): 4.22±0.10(Predicted)

색상: White to off-white

안전

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) C화학적 특성, 용도, 생산

개요

Cyclin-dependent kinases (Cdks) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. R547 is a diaminopyrimidine compound that inhibits Cdk1/cyclin B, Cdk2/cyclin E, and Cdk4/cyclin D1 (K_is = 1-3 nM). It is inactive against a panel of more than 120 unrelated kinases (K_is > 5 μM). R547 inhibits tumor cell proliferation (IC₅₀s ≤ 0.6 μM in vitro), inducing cell cycle arrest at G₁ and G₂ phases and apoptosis as well as reducing phosphorylation of the retinoblastoma protein. It also demonstrates antitumor activity in vivo in various human tumor xenograft models.

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 준비 용품 및 원자재

원자재

준비 용품

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 공급 업체

글로벌( 108)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 관련 검색:

Sulfanilamide AT7519 Selumetinib CAL-101 (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Rapamycin Abemaciclib mesylate (LY2835219) 2,4-Diamino-5-(3-fluorobenzyl)pyrimidine 2-(ISOPROPYLAMINO)PYRIMIDINE-5-CARBALDEHYDE 2'-FLUORO-6'-HYDROXYACETOPHENONE Benzaldehyde, 2,3-difluoro-6-hydroxy- (9CI) 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE R547 2'-FLUORO-6'-METHOXYACETOPHENONE