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Pyridomycin

Pyridomycin 구조식 이미지

카스 번호:: 18791-21-4

상품명:: Pyridomycin

동의어(영문):: Pyridomycin;3-Hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridylmethyl)-1,4-dioxa-8-azacyclododeca-6-yl]-2-pyridinecarboxamide;2-Pyridinecarboxamide, 3-hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridinylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-

CBNumber:: CB42282882

분자식:: C27H32N4O8

포뮬러 무게:: 540.57

MOL 파일:: 18791-21-4.mol

속성

안전

용도

공급 업체 31

Pyridomycin 속성

녹는점: 222°

끓는 점: 616.01°C (rough estimate)

밀도: 1.3105 (rough estimate)

굴절률: 1.6000 (estimate)

저장 조건: Store at -20°C

용해도: DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble

산도 계수 (pKa): 11.54±0.70(Predicted)

안전

Pyridomycin C화학적 특성, 용도, 생산

개요

Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml).

용도

Pyridomycin is a potent antibiotic active against mycobacteria and some Gram negative bacteria, originally isolated from Streptomyces abidoflavus by Umezawa group at the NIH Japan in 1953, and since isolated from different species and published under several names. The unusual 12-membered macrocyclic depsipeptide comprises three unique sub-units incorporating two substituted pyridines. Pyridomycin is thought to target NADH-dependent enoyl (acyl-carrier-protein) reductase InhA. Recent reports of activity against isoniazid-resistant mycobacteria has seen pyridomycin identified as a potential lead for new generation antibiotics.

Pyridomycin 준비 용품 및 원자재

원자재

준비 용품

Pyridomycin 공급 업체

글로벌( 31)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21662	55
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226	sales@rrkchem.com	China	56265	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Meng Cheng Technology (Shanghai) Co., LTD	400-820-6829	sales@mitachieve.com	China	8864	58
Zhejiang Huida Biotech Co., LTD	0571-89903882 13626641628	jiangnan@huidabiotech.com	China	3656	58

Pyridomycin 관련 검색:

Clindamycin Azithromycin Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Daptomycin Gentamicin