트레할로스 2수화물
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트레할로스 2수화물 속성
- 녹는점
- 97-99 °C(lit.)
- 끓는 점
- 115.3 °C
- 알파
- 179 º (c=2, H2O)
- 굴절률
- 181 ° (C=7, H2O)
- 저장 조건
- room temp
- 용해도
- H2O: 50 mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- optical activity
- [α]20/D +179±3°, c = 2% in H2O
- 수용성
- 68.9g/100mL(20℃)
- 감도
- Hygroscopic
- Merck
- 14,9580
- BRN
- 5322018
- InChIKey
- DPVHGFAJLZWDOC-NYAOJISMSA-N
- CAS 데이터베이스
- 6138-23-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 38-36/37/38 | ||
안전지침서 | 37/39-26-24/25 | ||
WGK 독일 | 2 | ||
RTECS 번호 | LZ5776547 | ||
F 고인화성물질 | 3-10 | ||
TSCA | Yes | ||
HS 번호 | 29400000 |
트레할로스 2수화물 C화학적 특성, 용도, 생산
개요
Trehalose is a natural non-reducing disaccharide composed of two α-glucose units. It is found in all major groups of organisms except vertebrates, has biological functions as an osmolyte, storage reserve, and stress protectant, and has diverse commercial applications. Trehalose can also induce or enhance autophagy.화학적 성질
white to off-white crystalline powder용도
D-(+)-Trehalose is a disaccharide composed of two α-glucose units. D-(+)-Trehalose is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations. D-(+)-Trehalose is also used as a protein stabilize.생산 방법
Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.일반 설명
Trehalose is a naturally occurring disaccharide which is used as a nontoxic cryoprotectant of enzymes, membranes and vaccines. It serves as a carbohydrate reserve in microorganisms and protects them from adverse conditions.Pharmaceutical Applications
D(+)-Trehalose dihydrate is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.Safety
Trehalose is used in cosmetics, foods, and parenteral and nonparenteral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.In the gut, trehalose is rapidly metabolized to glucose by the specific enzyme trehalase. A small minority of the population exhibits a primary (hereditary) or secondary (acquired) trehalase deficiency and thus may experience intestinal discomfort after ingestion of excessive amounts of trehalose owing to the osmotic activity of undigested trehalose in the gut. However, smaller amounts of trehalose are tolerated by such individuals without any symptoms.
Trehalose is used as a sweetener and is reported to have substantially less cariogenic potential than sucrose.
LD50 (dog, IV): >1 g/kg
LD50 (dog, oral): >5 g/kg
LD50 (mouse, IV): >1 g/kg
LD50 (mouse, oral): >5 g/kg
LD50 (rat, IV): >1 g/kg
LD50 (rat, oral): >5 g/kg
저장
Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).Trehalose should be stored in a cool, dry place in a well-sealed container.
Purification Methods
α,α-D(+)-Trehalose crystallises (as the dihydrate) from aqueous EtOH. Dry it at 13o. For the anhydrous compound dissolve 10g in pyridine (200mL) and distil off this solvent at atmospheric pressure, and when the temperature rises to 115.3o all the H2O is removed and 73mL of distillate is collected. Most of the anhydrous material crystallises out at this stage. The crystals are collected (6.8g), washed with Et2O to give 6.1g of anhydrous product. Higher yields are obtained by slightly more prolonged distillation. [Birch J Chem Soc 3489 1965, X-ray cryst: Brown et al. Acta Cryst 28 3145 1972, Beilstein 17/8 V 3.]비 호환성
Trehalose is incompatible with strong oxidizing agents, especially in the presence of heat.Regulatory Status
GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.트레할로스 2수화물 준비 용품 및 원자재
원자재
준비 용품
트레할로스 2수화물 공급 업체
글로벌( 481)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Shandong Juchuang Chemical Co., LTD | +undefined15030412209 |
admin@juchuangchem.com | China | 387 | 58 |
Apeloa production Co.,Limited | +8619933239880 |
admin@apcl.com.cn | China | 853 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 |
admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16914 | 58 |
트레할로스 2수화물 관련 검색:
갈락토아라비난 트레할로스 디에틸스틸베스트롤
D(+)-Malic acid
4-Hydroxy-D-(-)-2-phenylglycine
D-(+)-Cellobiose
L(+)-Rhamnose monohydrate
D(+)-Raffinose pentahydrate
L-xylose
Alkyl polyglucoside
Ginsenoside Rc
Tetrahydro-4H-pyran-4-one
Centchroman
FOROXYMITHINE
TREHALOSE OCTAACETATE
6,6'-DIBEHENOYL-ALPHA,ALPHA'-TREHALOSE
Actinotetraose Hexatiglate
D(+)-Trehalose dihydrate