소리부딘
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소리부딘 속성
- 녹는점
- 182° (Sakata, 1980); mp 195-200° (dec) (Machida, Sakata, 1983)
- 알파
- D25 +0.5° (1N NaOH)
- 밀도
- 1.979±0.06 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO: 250 mg/mL (716.07 mM)
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 8.37±0.10(Predicted)
- 색상
- White to off-white
안전
| 독성 | LD50 in mice (mg/kg): ~3300 i.p.; >5000 s.c.; >10000 orally (Machida, Sakata, 1984) |
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소리부딘 C화학적 특성, 용도, 생산
개요
Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of 20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream is also useful in the topical treatment of cutaneous HSV-1 infection, including immunocompromised patients. It has been suggested that its antiviral activity may be mediated by inhibition of DNA synthesis in virus infected cells.Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism, caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to avoid hematological disorders.
용도
Sorivudine is an antimetabolite drug and can be used to synthesize antiviral compounds as well as compounds that can treat diseases of viral etiol.소리부딘 준비 용품 및 원자재
원자재
준비 용품
소리부딘 공급 업체
글로벌( 24)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 |
info@pbpharm.com | CHINA | 498 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10978 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 |
sales01@watsonbiotech.cn | China | 5815 | 58 |
| LGM Pharma | 1-(800)-881-8210 |
inquiries@lgmpharma.com | United States | 2127 | 70 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 |
lxy2046@yeah.net | China | 480 | 55 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 |
service@aiviche.com | China | 49323 | 58 |
| Hangzhou Jinghao Biotechnology Co., LTD | 17513242016 17513242016 |
1576861551@qq.com | China | 2801 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| InvivoChem | 13549236410 |
sales@invivochem.cn | China | 6747 | 58 |