Hygroscopic, -20°C Freezer, Under inert atmosphere
용해도
DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
11.84±0.20(Predicted)
색상
흰색에서 황백색까지
안정성
흡습성
안전
위험 및 안전 성명
위험 및 사전주의 사항 (GHS)
그림문자(GHS):
신호 어:
Warning
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H302
삼키면 유해함
급성 독성 물질 - 경구
구분 4
경고
P264, P270, P301+P312, P330, P501
H315
피부에 자극을 일으킴
피부부식성 또는 자극성물질
구분 2
경고
P264, P280, P302+P352, P321,P332+P313, P362
H319
눈에 심한 자극을 일으킴
심한 눈 손상 또는 자극성 물질
구분 2A
경고
P264, P280, P305+P351+P338,P337+P313P
H335
호흡 자극성을 일으킬 수 있음
특정 표적장기 독성 - 1회 노출;호흡기계 자극
구분 3
경고
예방조치문구:
P261
분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312
삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P302+P352
피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
Narlaprevir C화학적 특성, 용도, 생산
개요
Narlaprevir was approved as a
treatment for genotype 1 HCV and serves as a class 2 HCV
NS3 serine protease inhibitor. In clinical trials, it showed a
rapid and steady decline in HCV-RNA levels in both previously
treated and treatment-naive patients when used in combination
with ritonavir and PEG-IFN-α. This combination ultimately
led to ≥50% of patients with undetectable HCV-RNA levels
after a second period of treatment. Narlaprevir also has
demonstrated activity against HCV mutations resistant to other
treatments such as boceprevir and telaprevir. The unique
activity of this drug can be attributed to a critical electrophilic
α-keto-amide “warhead”, which covalently reacts with an HCV
NS3 protease active-site serine residue involved in the HCV
viral replication process. Because of their essential roles in
viral replication, HCV NS3 and NS5B proteases have recently
become key targets for HCV drug development. Strategically,
the development of narlaprevir stems specifically from the
pursuit of a single-diastereomer, second generation HCV
protease inhibitor, which would provide in vitro potency and
pharmacokinetic profile improvements over the structurally
related antiviral drug boceprevir,which exists as a mixture of
diastereomers. After the R-Pharm pharmaceutical group
obtained the license to manufacture narlaprevir from Merck in
2012, further development of the drug was realized through
collaborations with Schering-Plough and Texas Liver Institute.
용도
Narlaprevir is an NS3/4A protease inhibitor used in the treatment of hepatitis C virus, HCV.
