보세프레비르

보세프레비르
보세프레비르 구조식 이미지
카스 번호:
394730-60-0
한글명:
보세프레비르
동의어(한글):
보세프레비르
상품명:
Boceprevir
동의어(영문):
CS-354;EBP 520;Sch 503034;Bocepravir;Boceprevir;Boceprevir, >=98%;Boceprevir(EBP 520;Boceprevir USP/EP/BP;Boceprevir(Sch 503034);TIANFUCHEM-- Boceprevir
CBNumber:
CB32491465
분자식:
C27H45N5O5
포뮬러 무게:
519.68
MOL 파일:
394730-60-0.mol
MSDS 파일:
SDS

보세프레비르 속성

녹는점
>107°C (dec.)
밀도
1.162
저장 조건
-20°C
용해도
DMSO에 용해됨(가온 시 최대 15mg/ml)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
12.82±0.40(Predicted)
색상
흰색 또는 황백색
안정성
제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
안전
  • 위험 및 안전 성명
HS 번호 2933599590
유해 물질 데이터 394730-60-0(Hazardous Substances Data)
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2 0

보세프레비르 C화학적 특성, 용도, 생산

개요

In May 2011, the U.S. FDA approved boceprevir (SCH-503034), to be given in combination with peginterferon alfa plus ribavirin, for the treatment of patients with chronic hepatitis C genotype 1 viral infection. Boceprevir and telaprevir are the first hepatitis C virus (HCV) protease inhibitors to be approved for the treatment of HCV infection. Boceprevir is an inhibitor of HCV NS3-4A protease, an essential enzyme required by HCV for posttranslational processing of viral proteins into their mature forms. Boceprevir binds covalently, but reversibly, to the active site serine by addition of the hydroxyl group to the keto-amide functionality. Boceprevir inhibits HCV NS3-4A protease with a Ki of 14 nM. In cell culture, the EC50 of boceprevir was 200 nM for an HCV replicon constructed from genotype 1b. Boceprevir was two-to threefold less potent against HCV replicon from genotypes 1a, 2, and 3. The potency of boceprevir decreased threefold in the presence of human serum. Boceprevir was discovered through a series of systematic truncations and modifications of a keto-amide undecapeptide lead molecule.
Boceprevir is synthesized by coupling of 3-amino-4- cyclobutyl-2-hydroxybutyramide or the related oxobutyramide with a cyclopropyl-pyrrolidine carboxylic acid intermediate. The pyrrolidine derivative can be prepared via cyclopropanation of a bicyclic lactam derivative or by conversion of 3,3-dimethylcyclopropane-1,2-dicarboxylic acid to the pyrrolidine in a multistep route. Boceprevir is a 1:1 mixture of diastereomers at the readily epimerizable position a to the keto group.

화학적 성질

Off-White to Pale Yellow Solid

용도

An NS3 serine protease inhibitor of hepatitis C virus, for the treatment of HCV infection. It is a COVID19-related research product.

정의

ChEBI: A synthetic tripeptide consisting of N-(tert-butylcarbamoyl)-3-methyl-L-valyl, a cyclopropyl-fused prolyl and 3-amino-4-cyclobutyl-2-oxobutanamide residues joined in sequence. Used for treatment of chronic h patitis C virus genotype 1 infection.

Clinical Use

Boceprevir is an oral inhibitor of HCV NS3/4A protease for the treatment of the chronic hepatitis C genotype infection. It is approved as combination therapy with Peg-IFN-alpha and ribavarin to treat adult patients with compensated liver diseasewhoare either treatment naive or who have experienced prior failed therapy with interferon and ribavarin. Boceprevir was initially discovered by Schering-Plough and developed and marketed by Merck & Co. since its acquisition of Schering-Plough in 2009. Several publications have highlighted the discovery of this drug, which evolved from a potent initial undecapeptide lead structure to boceprevir (VII) as a drug candidate with potent activity and desirable PK properties.

보세프레비르 준비 용품 및 원자재

원자재

준비 용품


보세프레비르 공급 업체

글로벌( 201)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Alpha Biopharmaceuticals Co., Ltd
+86-15542445688
sales@alabiochem.com China 888 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21677 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258 15093356674;
sales@coreychem.com China 29902 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 967 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49391 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-519-519-85557386
marketing1@neostarunited.com China 12414 58
Nanjing Fred Technology Co., Ltd.
+86-02584696168 15380713688
Austin@fredchem.cn CHINA 865 58
Shanxi Xuanran Import and Export Trade Co., Ltd.
+8617735180244
mike_yan@xuanranglobal.com CHINA 4022 58

보세프레비르 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved