이소프레날린 염산
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이소프레날린 염산 속성
- 녹는점
- 165-175 °C (dec.)(lit.)
- 끓는 점
- 192°C (rough estimate)
- 밀도
- 1.2296 (rough estimate)
- 굴절률
- 1.6000 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 물에 잘 녹고, 에탄올(96%)에 조금 녹고, 염화메틸렌에는 거의 녹지 않습니다.
- 물리적 상태
- 흰색 고체
- 색상
- 흰색에서 황백색까지
- 수용성
- 녹는
- BRN
- 3917363
- 안정성
- 안정적이지만 공기와 빛에 민감할 수 있습니다. 강한 산화제와 호환되지 않습니다.
- InChI
- InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
- InChIKey
- IROWCYIEJAOFOW-UHFFFAOYSA-N
- SMILES
- C1(=CC=C(O)C(O)=C1)C(O)CNC(C)C.Cl
- CAS 데이터베이스
- 51-30-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 2 | ||
RTECS 번호 | DO1925000 | ||
F 고인화성물질 | 3-8-10 | ||
HS 번호 | 29225090 | ||
독성 | LD50 oral in rabbit: 3070mg/kg |
이소프레날린 염산 C화학적 특성, 용도, 생산
개요
Isoprenaline hydrochloride is an FDA-approved injectable drug that is the hydrochloride form of isoprenaline and is used as a bronchodilator, adrenergic beta agonist, cardiotonic, and sympathomimetic. Selective beta-adrenergic agonist that increases cytoplasmic cAMP. promotes glycogenolysis and causes bronchodilation. Increases Cl- diffusion and potential difference in rabbit tracheal cells via nitric oxide production. In addition, it can be used as an inducer in an experimental rat model of induced myocardial infarction[1].화학적 성질
White or almost white, crystalline powder.용도
Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator.일반 설명
Odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air.공기와 물의 반응
May be sensitive to exposure to air and light. . Water soluble.반응 프로필
An acid organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.건강위험
SYMPTOMS: Symptoms of exposure to Isoprenaline hydrochloride may include tremors, nervous apprehension, palpitations of the heart, epigastric distress, cardiac arrhythmias, myocardial necrosis, cardiac arrest, tachycardia, headache, flushing of the skin, anginal pain, nausea, dizziness, weakness, and sweating.화재위험
Flash point data for Isoprenaline hydrochloride are not available. Isoprenaline hydrochloride is probably combustible.생물학적 활성
Standard selective β -adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β 2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo . Also available as part of the β -Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™ .참고 문헌
[1] FANG WANG. Fucoxanthin averts isoprenaline hydrochloride-induced myocardial infarction in rats[J]. Pharmacognosy Magazine, 2020, 16 1: 214-220. DOI:10.4103/pm.pm\_357\_19.이소프레날린 염산 준비 용품 및 원자재
원자재
준비 용품
이소프레날린 염산 공급 업체
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