FICZ;FICZ, 10 mM in DMSO;6-FORMYLINDOLO A CARBAZOLE;6-FORMYLINDOLO [3,2-B] CARBAZOLE;6-Formylindolo[3,2-b]carbazole (FICZ);Indolo[3,2-b]carbazole-6-carbaldehyde;5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde;inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ
제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 솔루션은 최대 1개월 동안 -20°에서 보관할 수 있습니다.
안전
위험 및 안전 성명
위험 및 사전주의 사항 (GHS)
WGK 독일
1
그림문자(GHS):
신호 어:
Warning
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H302
삼키면 유해함
급성 독성 물질 - 경구
구분 4
경고
P264, P270, P301+P312, P330, P501
예방조치문구:
NFPA 704
0
2
0
6-ForMylindolo[3,2-b]carbazole C화학적 특성, 용도, 생산
용도
6-Formylindolo[3,2-b]carbazole is a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma.
Biochem/physiol Actions
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.
