KANAMYCIN
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KANAMYCIN 속성
- 저장 조건
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 물리적 상태
- 액체
- 안정성
- 안정성 강산화제와 혼합할 수 없습니다.
안전
위험품 표기 | T | ||
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위험 카페고리 넘버 | 61 | ||
안전지침서 | 36/37/39-45-53 | ||
WGK 독일 | 2 | ||
HS 번호 | 29419000 |
KANAMYCIN C화학적 특성, 용도, 생산
개요
Kanamycin A belongs to the family on aminoglycoside antibiotics which consist of two or more aminosugars linked by glycosidic bonds to an aminocyclitol ring. It was isolated in Japan from Streptomyces kanamyceticus. Clinically, kanamycin is used as a sulfate. Currently, kanamycin is only rarely used; its main place is for the treatment of tuberculosis caused by multidrug-resistant Myobacterium tuberculosis strains .화학적 성질
solidIndications
Kanamycin A is similar to streptomycin and neomycines and has a broad spectrum of antimicrobial action. It is active with respect to most Gram-positive as well as Gram-negative microorganisms (staphylococci, gastric bacilli, rabbit fever, Fridlender’s bacillus, proteus, shigella, salmonella).It is used for treating sepsis, meningitis, osteomyelitis, periotonitis, pneumonia, pyelonephritis, pyelocystitis, infected wounds, and post-operational purulent complications caused by microorganisms sensitive to the drug. Synonyms of this drug are karmycin, kamaxin, resistomycin, and many others.
생물학적 활성
Kanamycin is considerably broader in spectrum than streptomycin, kanamycin is more effective against gram-negative bacilli (other than Pseudomonas) and also is effective to a degree against Staph. aureus. However, it is ineffective against streptococci and pneumococci. The availability of penicillinase-resistant penicillins and cephalosporins essentially obsoleted kanamycin as the primary drug in the treatment of staphylococcal infections. Kanamycin has been essentially replaced by gentamicin and other aminoglycosides which are less ototoxic (adverse to hearing), and which also have a wider range of antibacterial activity.Mechanism of action
Kanamycin and other aminoglycoside antibiotics interfere with bacterial protein synthesis. The drug binds to a particular protein or proteins of the 30S subunit of bacterial ribosomes. This results in a misreading (or miscoding) of mRNA codons. Consequently, wrong amino acids are incorporated into growing peptide chains and nonsense bacterial proteins are formed. This effect alone may not be lethal to bacteria, yet kanamycin and other aminoglycosides are rapidly bactericidal. Numerous hypotheses have been put forward over the years to explain this. The bactericidal property may be related to the very tight binding of aminoglycosides to the ribsomes, which is essentially irreversible. The most likely explanation seems to be that kanamycin also leads to the production of abnormal membrane proteins of the bacterial cell, which cause alterations in membrane permeability, and this plays an essential role in the bactericidal action.Drug interactions
All aminoglycosides are partially inactivated by high concentrations of any of the penicillins. In vitro, the penicillins inactivate kanamycin to about the same degree as gentamicin and tobramycin, but this occurs less readily with amikacin. Studies with gentamicin and amikacin have shown that heparin reversibly inhibits aminoglycoside activity in a dose-dependent way. This may also apply to kanamycin. Specimens for kanamycin measurements should not be obtained in heparinized tubes. Kanamycin excretion is not affected by probenecid.KANAMYCIN 준비 용품 및 원자재
원자재
준비 용품
KANAMYCIN 공급 업체
글로벌( 77)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8613917842738 |
info@longyupharma.com | China | 2534 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34571 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9030 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 |
Ethan@dornechem.com | China | 3146 | 58 |
Hebei Qige Biological Technology Co. Ltd | +86 +8618733132031 |
CHINA | 1313 | 58 | |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 25655 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15395 | 58 |
LUYUNJIA CHEMISTRY XIAMEN LIMITED | +86-592-5360779 +86-13055435203 |
China | 5996 | 58 |
KANAMYCIN 관련 검색:
아미카신 황산카나마이신
Acetylspiramycin
KANAMYCIN B SULFATE,KANAMYCIN B SULFATE SALT
KANAMYCIN B
KANAMYCIN,KANAMYCIN A,KANAMYCIN BASE
Kanamycin A disulfate salt,KANAMYCIN A ACID SULFATE,KANAMYCIN ACID SULFATE,KANAMYCIN ACID SULPHATE
Kanamycin Sulfate
KANAMYCIN SULFATE
KANAMYCIN A DISULFATE SALT DIHYDRATE
KANAMYCIN ESCULIN AZIDE AGAR
N'-[(S)-4-Amino-2-hydroxybutyl]kanamycin A
ANTI-HUMAN KANAMYCIN-BSA,ANTI-KANAMYCIN-BSA
Antibiotic Test disks, Kanamycin Susceptibility Test disks
E. coli growth agar with kanamycin, IPTG and X-gal, ready to use
KANAMYCIN POSITIVE CONTROL RNA
ANTI-KANAMYCIN