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글루카메타신

글루카메타신 구조식 이미지

카스 번호:: 52443-21-7

한글명:: 글루카메타신

동의어(한글):: 글루카메타신

상품명:: glucametacin

동의어(영문):: glucometacin;glucametacin;2-[[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetylamino]-2-deoxy-D-glucose;2-[[2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]-2-deoxy-D-glucose;D-Glucose, 2-[[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]-2-deoxy-

CBNumber:: CB5885480

분자식:: C25H27ClN2O8

포뮬러 무게:: 518.94

MOL 파일:: 52443-21-7.mol

속성

안전

용도

공급 업체 5

글루카메타신 속성

녹는점: >160°C (dec.)

끓는 점: 793.7±60.0 °C(Predicted)

밀도: 1.44

저장 조건: Refrigerator, under inert atmosphere

용해도: DMSO (약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 13.05±0.20(Predicted)

색상: 흰색에서 연한 노란색

안전

글루카메타신 C화학적 특성, 용도, 생산

Originator

Glucametacin,Shanghai Lansheng Corporation

Manufacturing Process

125 g (75 ml) thionyl chloride were added to 30 g 1-(p-chlorobenzoyl)-2- methyl-5-methoxy-indolyl-3-acetic acid (indometacine) in 200 ml of dry chloroform and heated to reflux for 15 min. The solvent was distilled off and the residue was recrystallized from benzene to give 23 g 1-(p-chlorobenzoyl)- 2-methyl-5-methoxy-indolyl-3-acetyl chloride. MP: 126°-129°C.
43 g d-(+)-glucosamine hydrochloride in 140 ml of cold water, 20 g above prepared acetyl chloride in any inert solvent (chloroform, ethyl acetate, dioxane) and 35 ml 12% NaOH was mixed and stirred for 1hour at a room temperature. Then it was diluted with water and a solid was filtered off, washed and dried in vacuum. 10 volumes (by weight) methanol was added to the obtained dry product, filtered off and dried in vacuum. Yield of 1-(pchlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid monohydrate glucosamide 20 g. Glucametacine was obtained as a powder. MP: about 218°C (with decomposition).

Therapeutic Function

Antiinflammatory, Analgesic, Antipyretic

Synthesis

glucametacin is prepared by acylation of d-glucosamine with indomethacin acid chloride (prepared from indomethacin and thionyl chloride) in the presence of sodium hydroxide.

글루카메타신 준비 용품 및 원자재

원자재

염화 티오닐 D-글루코사민 인드메타신

준비 용품

글루카메타신 공급 업체

글로벌( 5)공급 업체

공급자	전화	이메일	국가	제품 수	이점
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Hangzhou Yuhao Chemical Technology Co., Ltd	0571-82693216	info@yuhaochemical.com	China	9394	52
Hangzhou Jinghao Biotechnology Co., LTD	17513242016 17513242016	1576861551@qq.com	China	2801	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58

글루카메타신 관련 검색:

D-글루코사민 2-(1-BENZYL-1H-INDOL-3-YL)-ETHYLAMINE 2-(5-METHOXY-1H-INDOL-3-YL)-ACETAMIDE N-PROPIONYL-D-GLUCOSAMINE N-Isopropyl-5-methoxytryptamine glucametacin N-ACETYL-6-METHOXYTRYPTAMINE 2-METHYL-5-HYDROXYTRYPTAMINE 5-HYDROXYINDOLE-3-ACETAMIDE CHEMBRDG-BB 5102396 Benanserine N-ACETYL-5-HYDROXYTRYPTAMINE