Methazolamide
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Methazolamide 속성
- 녹는점
- 208 °C (dec.) (lit.)
- 끓는 점
- 402.0±28.0 °C(Predicted)
- 밀도
- 1.6625 (rough estimate)
- 굴절률
- 1.6270 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 용해성20mg/mL, 투명
- 산도 계수 (pKa)
- 7.30(at 25℃)
- 물리적 상태
- 백색분말
- 색상
- 흰색에서 베이지색
- 수용성
- 2.835g/L(25 ºC)
- InChIKey
- FLOSMHQXBMRNHR-QPJJXVBHSA-N
- CAS 데이터베이스
- 554-57-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 20/21/22-40 | ||
안전지침서 | 22-36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | AC6350000 | ||
HS 번호 | 2935904000 | ||
유해 물질 데이터 | 554-57-4(Hazardous Substances Data) |
Methazolamide C화학적 특성, 용도, 생산
개요
Methazolamide is a carbonic anhydrase inhibitor (IC50 = 130 nM). It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH. Methazolamide is larvicidal, with a larvicidal concentration (LC50) value of 724 ppm, but has no activity when administered in the diet to adult A. aegypti. Formulations containing methazolamide have been used for the treatment of glaucoma.화학적 성질
White Solid용도
Methazolamide is a carbonic anhydrase inhibitor. Methazolamide is used in the treatment of glaucoma.Clinical Use
Methazolamide is a derivative of acetazolamide in which one of the active hydrogens has been replaced by a methyl group. This decreases the polarity and permits a greater penetration into the ocular fluid, where it acts as a carbonic anhydrase inhibitor, reducing intraocular pressure. Its dose for glaucoma is 50 to 100 mg two to three times a day.Methazolamide 준비 용품 및 원자재
원자재
준비 용품
Methazolamide 공급 업체
글로벌( 191)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34571 | 58 |
WinWin Chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 |
sales@win-winchemical.com | China | 14278 | 58 |