클로로아세틸 클로라이드
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클로로아세틸 클로라이드 속성
- 녹는점
- −22 °C(lit.)
- 끓는 점
- 105-106 °C(lit.)
- 밀도
- 1.419 g/mL at 20 °C
- 증기 밀도
- 3.9 (vs air)
- 증기압
- 60 mm Hg ( 41.5 °C)
- 굴절률
- n
20/D 1.453(lit.)
- 인화점
- >100°C
- 저장 조건
- Store at RT.
- 용해도
- 에틸 에테르, 아세톤, 벤젠 및 사염화탄소와 혼합 가능합니다.
- 물리적 상태
- 액체
- 색상
- 무색투명~미황색
- 냄새
- 강한 자극적인 냄새
- 수용성
- 물과 반응
- 어는점
- -22.5℃
- 감도
- Moisture Sensitive
- Merck
- 14,2067
- BRN
- 605439
- 노출 한도
- ACGIH: TWA 0.05 ppm; STEL 0.15 ppm (Skin)
NIOSH: IDLH 1.3 ppm; TWA 0.05 ppm(0.2 mg/m3)
- 안정성
- 안정적인. 강염기, 알코올, 강산화제와 호환되지 않습니다. 물이나 습기에 노출되면 격렬하게 반응할 수 있습니다.
- CAS 데이터베이스
- 79-04-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,C,N | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 14-23/24/25-35-48/23-50-29 | ||
| 안전지침서 | 9-26-36/37/39-45-61-7/8 | ||
| 유엔번호(UN No.) | UN 1752 6.1/PG 1 | ||
| OEB | C | ||
| OEL | TWA: 0.05 ppm (0.2 mg/m3) | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | AO6475000 | ||
| TSCA | Yes | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | I | ||
| HS 번호 | 29159000 | ||
| 유해 물질 데이터 | 79-04-9(Hazardous Substances Data) | ||
| IDLA | 1.3 ppm (6 mg/m3) | ||
| 기존화학 물질 | KE-05500 |
클로로아세틸 클로라이드 C화학적 특성, 용도, 생산
화학적 성질
Chloroacetyl chloride is a colorless to yellowish liquid with a very pungent, extremely irritating, odor.용도
Chloroacetyl chloride is an intermediate in the production of alachlor and butachlor. It is used to prepare phenacyl chloride through Friedel-Crafts acylation of benzene.주요 응용
Chloroacetyl chloride can be used for chloroacetylation and chemical modification of poly(glycidyl methacrylate).Chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by rat and human liver microsomes. Chloroacetyl chloride was used in the synthesis of some novel quinoline derivatives having antileishmanial activity.
제조 방법
Chloroacetyl chloride is usually manufactured from chloroacetic acid by reaction with phosphorus trichloride, thionyl chloride, sulfuryl chloride, or phosgene. It is also obtained by chlorination of acetyl chloride in the presence of stronger aliphatic acids, preferably chloroacetic acids, or from sodium chloroacetate and the usual chlorinating agents.Koenig G et al; Chloroacetic Acids. Ullmann's Encyclopedia of Industrial Chemistry 7th ed. (1999-2018). NY, NY: John Wiley & Sons. Online Posting Date: October 15, 2012
정의
Chloroacetyl chloride is classified as an acyl halide. It is a colorless to light yellow liquid with a strong, pungent odor. This compound is highly toxic when inhaled and can corrode both metal surfaces and tissues.일반 설명
A colorless to light yellow liquid with a very pungent odor. Very toxic by inhalation. Corrosive to metals and tissue.반응 프로필
Chloroacetyl chloride reacts rapidly with water. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].위험도
Irritant to eyes, corrosive to skin. Upper respiratory tract irritant.건강위험
Inhalation causes severe irritation of upper respiratory system. External contact causes severe irritation of eyes and skin. Ingestion causes severe irritation of mouth and stomach.Safety Profile
Poison by ingestion and intravenous routes. Mildly toxic by inhalation. Corrosive. A lachrymator. When heated to decomposition it emits toxic fumes of Cl-.잠재적 노출
Highly toxic by inhalation. Chloroacetyl chloride is used in the manufacture of acetophenone. It is used in the manufacture of a number of pesticides including: alachlor, allidochlor, butachlor, dimethachlor, formothion, mecarbam, metolachlor, propachlor. It is also used in the manufacture of pharmaceuticals, such as chlordiazepoxide hydrochloride, diazepam, lidocaine, mianserin.Carcinogenicity
Chloroacetyl chloride was not genotoxic in a number of assays.운송 방법
UN1752 Chloroacetyl chloride, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive material, Inhalation Hazard Zone B.비 호환성
Reacts violently with water, steamforming chloroacetic acid and hydrogen chloride gas. Reacts with alcohols, powdered metals; sodium amide; combustibles; and many organics, causing toxic fumes, fire, and explosion hazard. On contact with air it emits corrosive gas. Decomposes when heated forming phosgene gas. Corrosive to metals.폐기물 처리
It may be discharged into sodium bicarbonate solution, then flushed to the sewer with water.클로로아세틸 클로라이드 준비 용품 및 원자재
원자재
준비 용품
4-(아세틸아미노)페닐클로로아세테이트
2-Chloro-N-(2,6-dimethylphenyl)acetamide
D-Serine
5-Methylthianaphthene
에틸1-(2-클로로아세틸)-4-피페리딘카복실레이트
2-Chloro-N,N-dimethylacetamide
Propacetamol
7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate
Benzyl 2-chloroacetate
2-AMINO-3-CYANO-4-CHLORO-5-FORMYLTHIOPHENE
D-Threonine
리도카인 수화염화물
CHLOROMETHYLACETAMIDE
프레틸라클로
데목세팜
2-AMINO-1-MORPHOLIN-4-YL-ETHANONE HCL
디클로페낙 나트륨
N-메틸-N-페닐-2-피페라진-1-일라세타미드
FLURAZEPAM
메톨라클로르
아닐로포스
Azasetron hydrochloride
D-Tyrosine
보네코르
클로로아세트산터셔리부틸에스테르
6-클로로-2-(클로로에틸)-3-옥시도-4-페닐-퀴나졸린
N-(2-벤조일-4-니트로페닐)-2-클로로아세트아미드
Praziquantel
Nitrazepam
Pirenzepine
모르포티온에멀젼
리도카인
Estazolam
다이아제팜
CHLOROTRIANISENE
a-클로로아세토페논
로라제팜
6-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE
2,2',4'-Trichloroacetophenone
Propachlor
클로로아세틸 클로라이드 공급 업체
글로벌( 424)공급 업체
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