rat,LC50,inhalation,4738mg/m3/4H (4738mg/m3),SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTIONLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: TREMOR,International Journal of Toxicology. Vol. 19, Pg. 333, 2000.
tert- 부틸 클로로 아세테이트는 투명한 무색 내지 황색의 액체이다. 제품 카테고리는 API 중간체, C6-C7, 카르 보닐 화합물 및 에스테르입니다.
용도
글리시 딜 에스테르의 축합에 사용됩니다. 또한 의약품, 농약 및 염료의 중간체로 사용할 수 있습니다.
독성
이 제품은 가연성이며 흡입, 피부 접촉 및 삼키면 유해합니다. 화상을 입을 수 있습니다. 또한 눈, 호흡계 및 피부에도 자극적입니다. 또한 수생 생물에게 매우 유독하며 수생 환경에 장기적인 악영향을 미칠 수 있습니다.
화학적 성질
clear colorless to yellow liquid. Hydrolysis generates tert-butanol and chloroacetic acid.
용도
tert-Butyl chloroacetate is used in the synthesis of imidazol-1-yl-acetic acid hydrochloride, cis-disubstituted aziridine ester via aza-Darzens reaction and 1,10-diaza-18-crown-6 based sensors bearing a coumarin fluorophore.
제조 방법
tert-Butyl chloroacetate synthesis: The tert-butanol was added to the mixture of chloroacetyl chloride and N,N-dimethylaniline, and the temperature was kept below 30°C. The reactant was poured into water, washed and dried, and then fractionated under reduced pressure. The fractions at 48-49°C (1.46kPa) were collected to obtain tert-butyl chloroacetate with a yield of 63%.
Safety Profile
A poison by ingestion.
Moderately toxic by inhalation skin contact.
S severe sluin and moderate eye irritant.
When heated to decomposition it emits
toxic vapors of Cl-.
Purification Methods
Check the NMR spectrum; if satisfactory then distil in a vacuum; if not then dissolve in Et2O, wash with H2O, 10% H2SO4 until the acid extract does not become cloudy when made alkaline with NaOH. Wash the organic layer again with H2O, then saturated aqueous NaHCO3, dry over Na2SO4, evaporate and fractionate it through a carborundum-packed column or a 6-inch Widmer column (p 11, see tert-butyl ethyl malonate for precautions to avoid decomposition during disillation). [Johnson et al. J Am Chem Soc 75 4995 1953, Baker Org Synth Coll Vol III 144 1944, Beilstein 2 III 444.]