ANTI-HUMAN CD42B

ANTI-HUMAN CD42B C화학적 특성, 용도, 생산

용도

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

일반 설명

The mouse monoclonal antibody AK2 recognizes CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.

Biochem/physiol Actions

Cluster of differentiation 42b (CD42b) clustering promotes integrin αIIbβ3-dependent platelet aggregation, phagocytosis and rapid platelet clearance in the liver. The encoded protein acts as a platelet receptor for von Willebrand factor (VWF) and other ligands present in circulation. Mutation in the gene leads to autosomal recessive Bernard-Soulier syndrome. CD42b interacts with plasma hemoglobin (Hb) and enhances platelet activation and apoptosis in a concentration-dependent manner and also regulates platelet functions.

ANTI-HUMAN CD42B 준비 용품 및 원자재

원자재

준비 용품

ANTI-HUMAN CD42B 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Suzhou Ruinuode Biotechnology Co., Ltd.	--	2090855807@qq.com	CHINA	6063	58
Nanjing Sai Ruirui Biotechnology Co., Ltd.	--	sales@shrbio.com	CHINA	6873	58
Beijing Huaxia Ocean Technology Co., Ltd.	--	huaxiabio@163.com	CHINA	6122	58
Shanghai Beinuo Biotechnology Co., Ltd.	--	beinuobio@163.com	CHINA	6580	58
Beijing Bi Orange Blue Biotechnology Co., Ltd.	--	bo49855987@163.com	CHINA	6827	58
Shanghai Minmin Biotechnology Co., Ltd.	--	1914109725@qq.com	CHINA	6530	58
Riedel-de Haen AG	--		United States	6825	87
EMD Biosciences, Inc.	--	technical@calbiochem.com	United States	6529	66
BIOTREND Chemikalien GmbH	--	jaeger@biotrend.com	Germany	6115	76
BD Biosciences	--		United States	5013	82