Esmolol
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Esmolol 속성
- 녹는점
- 48-50 °C
- 끓는 점
- 430.2±40.0 °C(Predicted)
- 밀도
- 1.026
- 저장 조건
- Store at -20°C
- 용해도
- DMSO: 59 mg/mL (199.75 mM);Ethanol: 59 mg/mL (199.75 mM)
- 산도 계수 (pKa)
- 13.88±0.20(Predicted)
- 수용성
- 약간 용해됨
- Merck
- 14,3700
- CAS 데이터베이스
- 81147-92-4(CAS DataBase Reference)
안전
| RTECS 번호 | DA8345500 |
|---|
Esmolol C화학적 특성, 용도, 생산
용도
Esmolol is a cardioselective beta1 receptor blocking agent.위험도
A reproductive hazard.Clinical Use
Esmolol (Brevibloc) is a short-acting intravenously administered β1-selective adrenoceptor blocking agent. It does not possess membrane-stabilizing activity or sympathomimetic activity.Esmolol is used in the treatment of supraventricular tachyarrhythmias for rapid control of ventricular rate and reduction of myocardial oxygen consumption. Discontinuation of administration is followed by a rapid reversal of its pharmacological effects because of esmolol’s rapid hydrolysis by plasma esterases.
부작용
The most frequently reported adverse effects are hypotension, nausea, dizziness, headache, and dyspnea.As with many β-blocking drugs, esmolol is contraindicated in patients with overt heart failure and those in cardiogenic shock.신진 대사
The -blocker esmolol (Brevibloc) is unusual in that it is very rapidly metabolized; its plasma half-life is only 9 minutes. It is subject to hydrolysis by cytosolic esterases in red blood cells to yield methanol and an acid metabolite, the latter having an elimination half-life of about 4 hours. Only 2% of the administered esmolol is excreted unchanged. Because of its rapid onset and short duration of action, esmolol is used by the intravenous route for the control of ventricular arrhythmias in emergencies.Esmolol 준비 용품 및 원자재
원자재
황산
염산
이소프로필아민
에피클로로하이드린
3-(4-하이드록시페닐)프로피온산
탄산 칼륨
메틸3-(4-하이드록시페닐)프로피오네이트
BENZENEPROPANOICACID,4-(OXIRANYLMETHOXY)-,METHYLESTER
4-브로모페놀
준비 용품
Esmolol 공급 업체
글로벌( 87)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ShanDong Look Chemical Co.,Ltd. | +8617653113219 |
sales01@sdlookchemical.com | China | 2737 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49374 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10473 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 |
kathy@hbyinsheng.com | China | 3512 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57505 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 |
niki@zlchemi.com | China | 3268 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 |
ellena@amitychem.com | China | 43416 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 |
sale@mainchem.com | China | 32343 | 55 |
| Jiangsu Chia Tai Feng Hai Pharmaceutical Co.,Ltd | 025-57033246-8069 |
weitianyu@ctfh.com.cn | China | 19 | 58 |
| LGM Pharma | 1-(800)-881-8210 |
inquiries@lgmpharma.com | United States | 2123 | 70 |