메틸리튬
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메틸리튬 속성
- 녹는점
- 70-71℃
- 끓는 점
- 88℃
- 밀도
- 0.85 g/mL at 20 °C
- 증기 밀도
- 3 (vs air)
- 인화점
- 5 °F
- 저장 조건
- 2-8°C
- 물리적 상태
- 액체
- 색상
- 무색~황색
- Specific Gravity
- 0.83
- 수용성
- 물과 반응합니다.
- 감도
- Air & Moisture Sensitive
- Hydrolytic Sensitivity
- 9: reacts extremely rapidly with atmospheric moisture - may be pyrophoric - glove box or sealed system required
- BRN
- 3587162
- 노출 한도
- ACGIH: TWA 400 ppm; STEL 500 ppm
OSHA: TWA 400 ppm(1200 mg/m3)
NIOSH: IDLH 1900 ppm
- CAS 데이터베이스
- 917-54-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F+,C,N,F,Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 12-15-17-22-34-66-67-65-51/53-11-36/37/38-36/38-19-40-36/37-37-14/15 | ||
안전지침서 | 16-26-36/37/39-45-43-30-60-62-61-36/37 | ||
유엔번호(UN No.) | UN 3399 4.3/PG 1 | ||
WGK 독일 | 2 | ||
F 고인화성물질 | 10 | ||
TSCA | Yes | ||
위험 등급 | 4.3 | ||
포장분류 | I | ||
HS 번호 | 29319090 | ||
기존화학 물질 | KE-24321 |
메틸리튬 C화학적 특성, 용도, 생산
화학적 성질
Methyllithium is a colorless to yellowish solution, It is insoluble in hydrocarbon solvents although propyllithium and the higher homologues are miscible in hydrocarbons. Methyllithium is soluble in diethyl ether to about 6% by weight at room temperature (with or without lithium bromide) and is a little less soluble in tetrahydrofuran. Cooling of these solutions produces clear, colorless crystals of methyllithium etherate. Methyllithium is stable to about 200°C, at which temperature it disproportionates to dilithiomethane and methane.
용도
There are no significant industrial uses of methyllithium, but it is widely used in the laboratory in Grignard type reactions.Methyllithium is an organolithium reagent mainly used for deprotonation and as a source of methyl anion. It is a strong base and a strong nucleophile.
제조 방법
Methyllithium is produced industrially by the reaction of methyl chloride or methyl bromide with lithium metal dispersion in diethyl ether. The reaction with methyl chloride yields a solution of methyllithium and a precipitate of lithium chloride which may be readily separated. When methyl bromide is used, the lithium bromide byproduct remains in solution and complexes with the methyllithium. This reduces the reactivity of the methyllithium and, in certain cases, affects its usefulness. On the other hand, the less reactive complex is more stable in diethyl ether. Methyllithium produced from methyl chloride contains only about 0.3 % lithium chloride in a 5 % solution in diethyl ether. It is more reactive than the lithium bromide complex, but decomposes at the rate of 1 % of the contained methyllithium per year (that is 5.00 % solution goes to 4.95 %) at room temperature. The decomposition by ether cleavage results in methane and ethylene formation which increases the pressure in the container on long storage. Methyllithium can be prepared easily in tetrahydrofuran but it has a half-life of only about 2 days at room temperature due to solvent cleavage.주요 응용
Methyllithium solution (1.6M in diethyl ether) has been used for the asymmetric allylic alkylation (AAA) of allylic electrophiles in the presence of a chiral copper catalyst. This protocol leads to the C-C bond formation of tertiary and quaternary stereogenic centers with high enantioselectivity. It can also be used for the synthesis of (?)-salsolidine by reacting with 6,7-dimethoxy-3,4-dihydroisoquinoline in the presence of (?)-sparteine as a chiral ligand.위험도
Flammable, dangerous fire and explosionrisk, self-ignites in air.메틸리튬 준비 용품 및 원자재
원자재
준비 용품
5'-BROMO-2'-CHLOROACETOPHENONE
5-AMINO-2-METHOXY-3-PICOLINE
트리스(트리메틸실릴)실란
L-Selenomethionine
디메톡시톨루엔
4-Chloro-alpha-methylstyrene
5-[1-(2,3-디메틸페닐)에틸]-1H-이미다졸
2-헥사논
3,5-Dichloro-4-Picoline
2-메틸-1,10-페난트롤린
디피바로일메탄
비닐리튬
4-(2,2-디메틸-6-메틸렌시클로헥실)부탄-2-온
N-에틸 사이클로헥실아민
4-클로로-2-메틸페놀
에틸2,4-디메틸-1H-피롤-3-카르복실레이트
1-메틸사이클로부탄올
1-시클로프로필-프로판-2-원
2-(1-아다만틸)프로판-2-올
메틸리튬 공급 업체
글로벌( 207)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8822 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
Richest Group Ltd | 18017061086 |
oled@richest-group.com | CHINA | 5601 | 58 |