인돌-3-카르비놀
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인돌-3-카르비놀 속성
- 녹는점
- 96-99 °C (lit.)
- 끓는 점
- 267.28°C (rough estimate)
- 밀도
- 1.1135 (rough estimate)
- 굴절률
- 1.5670 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 메탄올에 용해됨
- 물리적 상태
- 결정질 분말 또는 플레이크
- 산도 계수 (pKa)
- 15.10±0.10(Predicted)
- 색상
- 황백색에서 노란색-주황색까지
- BRN
- 121323
- 안정성
- 2-80C
- InChI
- InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2
- InChIKey
- IVYPNXXAYMYVSP-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2)C(CO)=C1
- LogP
- 1.366 (est)
- CAS 데이터베이스
- 700-06-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
인돌-3-카르비놀 C화학적 특성, 용도, 생산
화학적 성질
Indole-3-carbinol is an off-white powder. It is soluble in organic solvents such as benzene, ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of Indole-3-carbinol in ethanol and DMF is approximately 10 mg/ml and approximately 3 mg/ml in DMSO. Indole-3-carbinol is an unstable compound that undergoes rapid oligomerization in acid pH environments, like the stomach.출처
Indole-3-carbinol is produced by members of the family Cruciferae, and particularly members of the genus Brassica (e.g., cabbage, radishes, cauliflower, broccoli, Brussels sprouts, and daikon).용도
Indole-3-carbinol has been used for encapsulation with poly-lactic-co-glycolic acid (PLGA), to study its in-vitro anti-cancerogenic effects on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. It has also been used as a cytochrome P4501A (CYP1A) inducer.제조 방법
Using indole, phosphorus oxychloride and N,N-dimethylformamide as raw materials, indole-3-carbaldehyde was synthesized by Vilsmeier-Haack reaction with a yield of 87.1%.정의
ChEBI: Indole-3-carbinol is an indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.주요 응용
Indole-3-carbinol (I3C) is a secondary plant metabolite of 3-methylindole produced in Brassica family vegetables. It is an inhibitor of Amyloid-beta deposition and Inhibits cancinogenesis at the initiation stage. Indole-3-carbinol is used in cancer prevention, specifically for breast, cervical and colon cancers. It has also been widely used to address lupus.일반 설명
Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts.Anticancer Research
I3C is a bioactive compound majorly found in Brassica vegetables including broccoli,cauliflower, and collard greens. I3C and its derivative diindolylmethane (DIM)have been investigated for cancer prevention and treatment of breast, prostate, andovarian cancers. I3C partially modulates the tyrosine kinase/PI3K/Akt signalingpathway which leads to the prevention of lung adenocarcinoma which is induced byusing tobacco carcinogen in A/J mice. DIM transduces signaling via aryl hydrocarbon(Ah) receptor, NF-κB/Wnt/Akt/mTOR signaling pathways, cell cycle arrest,modulated cytochrome P450 enzymes, and altered angiogenetic and invasive,metastatic, and epigenetic behavior of cancer cells. Combination of DIM and I3Cinduces Nrf2-mediated phase II drug metabolizing genes (GSTm2, UGT1A1, andNQO1) and antioxidant genes (HO-1, SOD-1) (Weng et al. 2008; 2012).인돌-3-카르비놀 준비 용품 및 원자재
원자재
준비 용품
인돌-3-카르비놀 공급 업체
글로벌( 729)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 |
sales@qinmuchem.com | China | 1009 | 58 |
Suzhou Yuanrui Bio-Tech Co., Ltd | +86-18106132862 +86-18106132862 |
sales02@yuanruibio.com | China | 285 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3320 | 58 |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 918 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales06@airuikechemical.com | China | 983 | 58 |
인돌-3-카르비놀 관련 검색:
3-인돌부틸산 인드메타신 인돌-3-아세트산 인돌 메틸알콜
INDOLE-4-METHANOL
INDOLE-5-METHANOL
3-Indolepropionic acid
3-Indoleacetonitrile
Indol-1-yl-acetic acid
Indole-3-carboxaldehyde
Indoline
2-(1H-indol-3-yl)acetaldehyde
Indole-2-carboxaldehyde
Methyl indole-3-carboxylate
Indole-3-carboxylic acid
Methyl indole-5-carboxylate
Indole-6-carboxaldehyde