Mirogabalin besylate

Mirogabalin besylate 구조식 이미지
카스 번호:
1138245-21-2
상품명:
Mirogabalin besylate
동의어(영문):
Mirogabalin Besilate;Mirogabalin besylat;Mirogabalin besylate;Mirogabalin Besylate 10928;MIROGABALIN BENZENESULFONIC ACID;Mirogabalin besylate (DS 5565 besylate);2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid besylate;[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0] hept-3-en-6-yl]acetic acid benzenesulfonate;((1R,5S,6S)-6-(carboxymethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)methanaminium benzenesulfonate;2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid compound with benzenesulfonic acid (1:1)
CBNumber:
CB73175483
분자식:
C18H25NO5S
포뮬러 무게:
367.46
MOL 파일:
1138245-21-2.mol

Mirogabalin besylate 속성

저장 조건
Store at -20°C
용해도
DMSO : 125 mg/mL (340.17 mM)
물리적 상태
Solid
색상
White to off-white
InChI
InChI=1/C12H19NO2.C6H6O3S/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8;7-10(8,9)6-4-2-1-3-5-6/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15);1-5H,(H,7,8,9)/t9-,10-,12-;/s3
InChIKey
OKJXJRVWXYRSAN-QWGAVYBYNA-N
SMILES
S(C1C=CC=CC=1)(O)(=O)=O.C([C@]1(C[C@@]2([H])CC(CC)=C[C@@]12[H])CN)C(=O)O |&1:11,13,20,r|

안전

Mirogabalin besylate C화학적 특성, 용도, 생산

개요

Mirogabalin besylate (mirogabalin, Tarlige) is a gabapentinoid therapy developed by Daiichi Sankyo, which is approved in Japan for the treatment of postherpetic neuralgia and painful diabetic peripheral neuropathy. Mirogabalin has a potent pain-modulating effect with a unique high affinity and prolonged dissociation rate for the a2delta-1 subunit of voltage-gated calcium (Ca2+) channels (VGCCs) on the dorsal root ganglion resulting in more sustained analgesia compared with traditional gabapentinoids[1].

용도

Mirogabalin besylate is an oral gabapentin analogue for the treatment of peripheral neuralgia (PNP), including diabetic PNP and postherpetic neuralgia. The drug has been approved in Japan for the treatment of PNP and has not yet received FDA approval.

Mirogabalin besylate 준비 용품 및 원자재

원자재

준비 용품


Mirogabalin besylate 공급 업체

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