A[5′]P5[5′]나트륨소금
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A[5′]P5[5′]나트륨소금 속성
- 저장 조건
- -20°C
- 용해도
- H2O: 50 mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 노란색을 띠는 흰색
- BRN
- 4949216
안전
WGK 독일 | 3 | ||
---|---|---|---|
F 고인화성물질 | 10-21 |
A[5′]P5[5′]나트륨소금 C화학적 특성, 용도, 생산
용도
P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt has been used as:- an adenylate kinase (AK) inhibitor in: sarcoma osteogenic (Saos-2) cells
- mitochondrial lysates during ATP synthesis
- tetramethylrhodamine methyl ester (TMRM) based membrane potential assay
- chromoplasts
일반 설명
P1,P5-Di(adenosine-5′) pentaphosphate (Ap5A) is a diadenosine polyphosphate, which has a tail-to-tail dimer structure. Ap5A is synthesized in a twostep process involving the formation of adenosine 5′-tetraphosphate (P4A) from the ATP and trimeta-phosphate (P3). In the second step, P4A is converted to Ap5A. The synthesis of Ap5A requires a pH optimum in the range of 7.5 to 8.5 and is modulated by metal ions.Biochem/physiol Actions
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.A[5′]P5[5′]나트륨소금 준비 용품 및 원자재
원자재
준비 용품
A[5′]P5[5′]나트륨소금 공급 업체
글로벌( 32)공급 업체
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