TOCAINIDE
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TOCAINIDE 속성
- 녹는점
- 246-266 °C
- 끓는 점
- 328.25°C (rough estimate)
- 밀도
- 1.0529 (rough estimate)
- 굴절률
- 1.5750 (estimate)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- pKa 7.75(H2O t = 25.0±0.2 I = 0.01 (NaCl)) (Uncertain)
- 색상
- White to off-white
- CAS 데이터베이스
- 41708-72-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): |
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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TOCAINIDE C화학적 특성, 용도, 생산
용도
Tocainide is used for suppressing symptoms of ventricular arrhythmia and tachycardia, and for premature cardiac contractions.정의
ChEBI: A monocarboxylic acid amide in which 2,6-dimethylphenylaniline and isobutyric acid have combined to form the amide bond; used as a local anaesthetic.World Health Organization (WHO)
Tocainide, an antidysrhythmic agent, was introduced in 1981 for the treatment of ventricular dysrhythmias. By 1984 its use was associated with cases of agranulocytosis, aplastic anaemia and thrombocytopenia, some of which were fatal. This led some regulatory authorities to restrict the indications for its use. The major manufacturer has subsequently restricted its use on a worldwide basis to the treatment of symptomatic ventricular dysrhythmias not responding to other therapy, or when other therapy is contraindicated.Pharmacokinetics
The α-methyl group is believed to slow the rate of metabolism and, thereby, to contribute to oral activity. The plasma half-life of tocainide is approximately 12 hours, and nearly 50% of the drug may be excreted unchanged in the urine. Adverse effects associated with tocainide are like those observed with lidocaine—specifically, gastrointestinal disturbances and central nervous system effects.Clinical Use
Tocainide (Tonocard) is an orally effective antiarrhythmic agent with close structural similarities to lidocaine. Tocainide is indicated for the treatment of symptomatic ventricular arrhythmias refractory to more conventional therapy. Serious noncardiac adverse effects limit its use to patients with life-threatening arrhythmias.부작용
Light-headedness, dizziness, or nausea occurs in approximately 15% of patients, paresthesias and numbness in 9%, and tremor in 8%.These adverse effects are generally mild in intensity, transient, and dose related. Overall, however, approximately 20% of patients prescribed tocainide discontinue therapy because of such effects. Serious immune-based side effects, such as pulmonary fibrosis, have been reported, and blood dyscrasias, such as agranulocytosis and thrombocytopenia, may occur in up to 0.2% of patients.Drug interactions
When used with other class IB antiarrhythmic drugs, tocainide toxicity may be increased without significant gain in antiarrhythmic efficacy.주의 사항
Patients who are hypersensitive to tocainide or to local anesthetics of the amide type should not be exposed to tocainide.The presence of second- or third-degree heart block in the absence of an artificial pacemaker also contraindicates the use of tocainide.TOCAINIDE 준비 용품 및 원자재
원자재
준비 용품
TOCAINIDE 공급 업체
글로벌( 60)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Wuxi Rejoys chemical Technology Co., Ltd. | 0510-86103381 |
sales@rejoyschem.com | CHINA | 976 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 8840 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Mainchem Co., Ltd. | +86-0592-6210733 |
sale@mainchem.com | China | 32360 | 55 |
LGM Pharma | 1-(800)-881-8210 |
inquiries@lgmpharma.com | United States | 2127 | 70 |
BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 14059 | 65 |
TOCAINIDE 관련 검색:
Bupivacaine hydrochloride
Mepivacaine hydrochloride
Mepivacaine
Bupivacaine
TOCAINIDE
TOCAINIDE HYDROCHLORIDE (125 MG),TOCAINIDE HCL,tocainide hydrochloride
TOCAINIDE
Bumecaine
N-(2,6-DIETHYLPHENYL)-1-([3-(TRIFLUOROMETHYL)PHENYL]SULFONYL)-2-PYRROLIDINECARBOXAMIDE
N-(1-(2,6-DIMETHYLPHENYLAMINO)-2-METHYL-1-OXOBUTAN-2-YL)-N-METHYL-2-PHENYLQUINOLINE-4-CARBOXAMIDE
N-(1-(2,6-DIMETHYLPHENYLCARBAMOYL)CYCLOHEXYL)-2-FLUOROBENZAMIDE
N-[1-(2,4-DICHLOROPHENYL)-2-(2,6-DIMETHYLANILINO)-2-OXOETHYL]-4-METHOXY-N-METHYLBENZAMIDE
AURORA KA-3187
N-{1-(2,4-DICHLOROPHENYL)-2-[(2,6-DIMETHYLPHENYL)AMINO]-2-OXOETHYL}-2-HYDROXYBENZAMIDE
N-(1-(2,6-DIMETHYLPHENYLCARBAMOYL)CYCLOHEXYL)-N-(2-HYDROXYETHYL)BENZAMIDE
N-(2,6-DIMETHYLPHENYL)-1-(2-(1,3-DIOXOISOINDOLIN-2-YL)-N-P-TOLYLACETAMIDO)CYCLOHEXANECARBOXAMIDE
N-(1-(2,6-DIMETHYLPHENYLCARBAMOYL)CYCLOHEXYL)-N-(4-METHOXYPHENYL)PICOLINAMIDE
N-[2-(2-ETHYL-6-METHYLANILINO)-2-OXO-1-PHENYLETHYL]-2-FLUORO-N-ISOBUTYLBENZAMIDE