1-Fluoronaphthalene
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1-Fluoronaphthalene 속성
- 녹는점
- -13 °C (lit.)
- 끓는 점
- 215 °C (lit.)
- 밀도
- 1.1322 g/mL at 20 °C (lit.)
- 굴절률
- n
20/D 1.593(lit.)
- 인화점
- 150 °F
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 물에 약간 용해되고 클로로포름, 에틸 아세테이트 및 메탄올에 잘 용해됩니다.
- 물리적 상태
- 기름
- 색상
- 무색~황색
- Specific Gravity
- 1.332
- 수용성
- 물에 섞이거나 혼합하기 어렵지 않습니다.
- BRN
- 1906413
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- CWLKTJOTWITYSI-UHFFFAOYSA-N
- CAS 데이터베이스
- 321-38-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
유엔번호(UN No.) | UN2810 | ||
WGK 독일 | 3 | ||
RTECS 번호 | QJ7100000 | ||
위험 참고 사항 | Flammable | ||
TSCA | T | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29039990 |
1-Fluoronaphthalene C화학적 특성, 용도, 생산
화학적 성질
clear slightly yellow to yellow-brown liquid용도
1-Fluoronaphthalene is a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. It is also used as a pharmaceutical intermediate. It is Duloxetine impurity.주요 응용
1-Fluoronaphthalene was used in t-BuLi-mediated synthesis of 6-substituted phenanthridines. It was also used in the synthesis of LY248686, a potent inhibitor of serotonin and norepinephrine uptake.제조 방법
The preparation of 1-Fluoronaphthalene is as follows:1) Diazotization reaction: 1500 g of hydrochloric acid (mass concentration: 25%) and 300 g of naphthylamine were added to a 3000 mL three-necked flask, stirred and heated to 75 ° C to dissolve, and the temperature was lowered to below 5 ° C, and 148 g was slowly added at this temperature. Sodium nitrite, stirred at low temperature for 0.3 hours after the addition, to obtain a diazonium salt solution;2) Substitution reaction: 360 g of fluoroboric acid solution (concentration: 45%) was added to the resulting solution obtained in the step 1), stirred for 0.25 h, filtered, and the filter cake was dried at a temperature of 50 ° C for 0.2 h to obtain Dry naphthylamine diazonium salt fluoroborate double salt;3) Hot air decomposition: the dried diazonium salt fluoroborate double salt is slowly added to the reactor through which hot air (hot air temperature is 85-90 ° C), and the dried powdered naphthylamine diazonium salt fluoroborate double salt is The hot air blows up the dispersion and absorbs the heat for thermal decomposition to obtain a 1-fluoronaphthalene solution containing a small amount of solid impurities;4) Purification treatment: the 1-fluoronaphthalene solution obtained in the step 3) is first washed with pure water for 3 to 6 times, then neutralized with a soda ash to a pH of 6.8 to 7.2, and finally the oil layer is separated by filtration, and the filtrate is taken. The distillation treatment gave 210 g of a naphthalene-based fluorine-containing intermediate 1-fluoronaphthalene in an amount of 99.8%.공기와 물의 반응
Insoluble in water.반응 프로필
Simple aromatic halogenated organic compounds, such as Fluoronaphthalene, are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.1-Fluoronaphthalene 준비 용품 및 원자재
원자재
준비 용품
4-Fluoronaphtalene-1-boronic acid
2-(1-FLUORONAPHTHALEN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE
(R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine
둘록세틴
3-브로모-1-플루오로나프탈렌
(S)-(+)-N,N-디메틸-3-(1-나프탈레닐옥시)-3-(2-티에닐)프로판아민
2-(1-나프틸렌)-4,4,5,5-테트라메틸-1,3,2-디옥사보롤란
1-fluoro-2-iodonaphthalene
4-FLUORONAPHTHALENE-1-SULFONYL CHLORIDE
(S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)
3-브로모-1-플루오로-2-요오도나프탈렌
(S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)
Duloxetine Impurity 4
1-Fluoronaphthalene 공급 업체
글로벌( 691)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hangzhou Verychem Science And Technology Co.Ltd | +86-86-57188162785 13606544505 |
lucy@verychem.com | China | 1054 | 58 |
Changzhou waston chemical technology Co.,Ltd | +86-051985861892 +8618112881323 |
info@wastonchem.com | China | 260 | 58 |
Wuhan ShuEr Biology Technology Co.,Ltd | +86-15629032529 |
excellentsuppliers@shuerbio.com | China | 897 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12834 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5889 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8617732866630 |
bess@weibangbio.com | China | 18150 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10986 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20283 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@sdzhonghuimaterial.com | China | 983 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 |
angelia@hbmojin.com | China | 1176 | 58 |
1-Fluoronaphthalene 관련 검색:
퍼플로로데카린 4-플루오로-1-나프토산 플루오린(불소) 6-플루오로-2-나프토산
4-FLUORONAPHTHALENE-1-SULFONYL CHLORIDE,4-FLUORONAPHTHALENE-1-SULPHONYL CHLORIDE
1-Bromo-4-fluoronaphthalene 98%,1-Bromo-4-fluoronaphthalene,98%,1-BROMO-4-FLUORONAPHTHALENE
1-ACETYL-4-FLUORONAPHTHALENE, 97%
4-FLUORONAPHTHALENE-1-BORONIC ACID,4-Fluoronaphthalene-1-boronic acid ,98%
Octafluoronaphthalene
1-Fluoronaphthalene
1-Fluoro-4-nitronaphthalene
2-AMINOHEPTAFLUORONAPHTALENE
1-CYANO-4-FLUORONAPHTHALENE,4-Fluoronaphthalene-1-carbonitrile, 97%
1-Amino-4-fluoronaphthalene
1-AMINO-8-FLUORONAPHTHALENE
2-FLUORENECARBOXALDEHYDE
beta-Fluoronaphthalene,2-FLUORONAPHTHALENE,2-Fluoronaphthalene solution,2-FLUORONAPHTHALENE, 100MG, NEAT
4-BROMO-1-FLUORONAPHTHALENE-2-BORONIC ACID,4-Bromo-1-fluoronaphthalene-2-boronic acid 98%,4-Bromo-1-fluoronaphthalene-2-boronicacid98%