1-Fluoronaphthalene

1-Fluoronaphthalene Properties

Melting point	-13 °C (lit.)
Boiling point	215 °C (lit.)
Density	1.1322 g/mL at 20 °C (lit.)
refractive index	n20/D 1.593(lit.)
Flash point	150 °F
storage temp.	Sealed in dry,Room Temperature
solubility	slightly soluble in water, well soluble in chloroform, ethyl acetate, and methanol.
form	Oil
color	Colourless to Yellow
Specific Gravity	1.332
Water Solubility	Not miscible or difficult to mix in water.
BRN	1906413
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	CWLKTJOTWITYSI-UHFFFAOYSA-N
CAS DataBase Reference	321-38-0(CAS DataBase Reference)
FDA UNII	0920702UT7
NIST Chemistry Reference	Naphthalene, 1-fluoro-(321-38-0)
EPA Substance Registry System	1-Fluoronaphthalene (321-38-0)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

UN2810

WGK Germany

3

RTECS

QJ7100000

Hazard Note

Flammable

TSCA

T

HazardClass

IRRITANT

HS Code

29039990

NFPA 704

	2
1		0

1-Fluoronaphthalene price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	196657	1-Fluoronaphthalene 99%	321-38-0	5g	$40.6	2024-03-01	Buy
Sigma-Aldrich	196657	1-Fluoronaphthalene 99%	321-38-0	25g	$120	2024-03-01	Buy
TCI Chemical	F0212	1-Fluoronaphthalene >98.0%(GC)	321-38-0	5g	$19	2024-03-01	Buy
TCI Chemical	F0212	1-Fluoronaphthalene >98.0%(GC)	321-38-0	25g	$45	2024-03-01	Buy
Alfa Aesar	A18378	1-Fluoronaphthalene, 98%	321-38-0	5g	$31.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
196657	5g	$40.6	Buy
196657	25g	$120	Buy
F0212	5g	$19	Buy
F0212	25g	$45	Buy
A18378	5g	$31.65	Buy

1-Fluoronaphthalene Chemical Properties,Uses,Production

Chemical Properties

clear slightly yellow to yellow-brown liquid

Uses

1-Fluoronaphthalene is a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. It is also used as a pharmaceutical intermediate. It is Duloxetine impurity.

Application

1-Fluoronaphthalene was used in t-BuLi-mediated synthesis of 6-substituted phenanthridines. It was also used in the synthesis of LY248686, a potent inhibitor of serotonin and norepinephrine uptake.

Preparation

The preparation of 1-Fluoronaphthalene is as follows:1) Diazotization reaction: 1500 g of hydrochloric acid (mass concentration: 25%) and 300 g of naphthylamine were added to a 3000 mL three-necked flask, stirred and heated to 75 ° C to dissolve, and the temperature was lowered to below 5 ° C, and 148 g was slowly added at this temperature. Sodium nitrite, stirred at low temperature for 0.3 hours after the addition, to obtain a diazonium salt solution;2) Substitution reaction: 360 g of fluoroboric acid solution (concentration: 45%) was added to the resulting solution obtained in the step 1), stirred for 0.25 h, filtered, and the filter cake was dried at a temperature of 50 ° C for 0.2 h to obtain Dry naphthylamine diazonium salt fluoroborate double salt;3) Hot air decomposition: the dried diazonium salt fluoroborate double salt is slowly added to the reactor through which hot air (hot air temperature is 85-90 ° C), and the dried powdered naphthylamine diazonium salt fluoroborate double salt is The hot air blows up the dispersion and absorbs the heat for thermal decomposition to obtain a 1-fluoronaphthalene solution containing a small amount of solid impurities;4) Purification treatment: the 1-fluoronaphthalene solution obtained in the step 3) is first washed with pure water for 3 to 6 times, then neutralized with a soda ash to a pH of 6.8 to 7.2, and finally the oil layer is separated by filtration, and the filtrate is taken. The distillation treatment gave 210 g of a naphthalene-based fluorine-containing intermediate 1-fluoronaphthalene in an amount of 99.8%.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Simple aromatic halogenated organic compounds, such as Fluoronaphthalene, are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

1-Fluoronaphthalene synthesis

Synthesis of 1-Fluoronaphthalene from 1-Naphthylamine

1-Fluoronaphthalene Preparation Products And Raw materials

Raw materials

Preparation Products

4-Fluoronaphtalene-1-boronic acid 2-(1-FLUORONAPHTHALEN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE (R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Duloxetine 3-Bromo-1-fluoronaphthalene

(S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine 2-(1-NAPHTHYLENE)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 1-fluoro-2-iodonaphthalene 4-FLUORONAPHTHALENE-1-SULFONYL CHLORIDE (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)

3-Bromo-1-fluoro-2-iodonaphthalene (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1) Duloxetine Impurity 4

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1-Fluoronaphthalene Suppliers

Global( 711)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Verychem Science And Technology Co.Ltd	+86-86-57188162785 13606544505	lucy@verychem.com	China	1093	58
Changzhou waston chemical technology Co.,Ltd	+86-051985861892 +8618112881323	info@wastonchem.com	China	296	58
Wuhan ShuEr Biology Technology Co.,Ltd	+86-15629032529	excellentsuppliers@shuerbio.com	China	897	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12806	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18137	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	10983	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20232	58
airuikechemical co., ltd.	+86-18353166132 +86-18353166132	sales02@airuikechemical.com	China	983	58

Supplier	Advantage
Hangzhou Verychem Science And Technology Co.Ltd	58
Changzhou waston chemical technology Co.,Ltd	58
Wuhan ShuEr Biology Technology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58

View Lastest Price from 1-Fluoronaphthalene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-29	1-Fluoronaphthalene 321-38-0	US $0.00-0.00 / kg	1kg	98	1000	Wuhan Circle Star Chem-medical Technology Co.,Ltd
2025-04-28	1-Fluoronaphthalene 321-38-0	US $0.00-0.00 / kg	1kg	99.99%	20 tons	Chongqing Soarwin Technology Co., Ltd
2025-04-23	1-Fluoronaphthalene 321-38-0	US $1.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

1-Fluoronaphthalene
321-38-0
US $0.00-0.00 / kg
98
Wuhan Circle Star Chem-medical Technology Co.,Ltd

1-Fluoronaphthalene
321-38-0
US $0.00-0.00 / kg
99.99%
Chongqing Soarwin Technology Co., Ltd

1-Fluoronaphthalene
321-38-0
US $1.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-Fluoronaphthalene Spectrum

1-Fluoronaphthalene(321-38-0)MS 1-Fluoronaphthalene(321-38-0)¹HNMR 1-Fluoronaphthalene(321-38-0)¹³CNMR 1-Fluoronaphthalene(321-38-0)IR1 1-Fluoronaphthalene(321-38-0)Raman

321-38-0(1-Fluoronaphthalene)Related Search:

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1-Fluoronaphth Duloxetine Hydrochloride impurity G 1-FLUORONAFTALENO Fluorophthalene alpha-Fluoronaphthalene 1-FLUORONAPHTHALENE 1-FLUORONAPHTHALENE, 1000MG, NEAT I-Fluoronaphthalene 1-Fluoronaphthalene99% I-Fluornaphthalin 1-Fluoronaphthalene,98% 1-Fluoronaphthalene solution 48720-u 1-fluoro-naphthalen NSC 4690 α-fluorinated naphthalene Duloxetine USP IMpurity G naphthyl fluoride C10H7F, α Duloxetine EP IMpurity G 1 - fluorinated naphthalene Naphthalene,1-fluoro- 1-Fluoronaphthalene, 97+% 1-fluoromaphthalene 1-Fluoronaphthalene 99.5% low price 1-Fluoronaphthalene 321-38-0 Duloxetine Impurity 13 uoronaphthaL Duloxetine EP Impurity G (USP RC G) 1-FLUORONAPHTHALENE NEAT low price 1-Fluoronaphthalene Duloxetine impurity G Duloxetine-8 1-fluoronaphthlene 1-Fluoronaphthalene@2.0 mg/mL in Dichloromethane 1-Fluoronaphthalene@0.2 mg/mL in CH2Cl2 1-Fluoronaphthalene @0.1 mg/mL in Acetone 2-Fluorobiphenyl & 1-Fluoronaphthalene@2.0 mg/mL in CH2Cl2 1-FluoronaphthaleneSolution,1,000mg/L,1mL 1-Fluornaphthalin Duloxetine EP Impurity G (α-fluonaphthalene) 1 - fluorinated naphthalene Finn 1-fluoronaphthalene(For export only) 1-Fluoronaphthalene ISO 9001：2015 REACH α-Fluoronaphthalene 1-Fluoronaphthalene (Duloxetine Impurity) Duloxetine Imp-G Duloxetine Impurity58 1-FLUORONAPTHALENE Fluoronaphthalene 1-Fluornaftalen Duloxetine Impurity 13(Duloxetine EP Impurity G) Duloxetine Hydrochloride EP Impurity G 1-Fluorinaphthalene 1-Fluornaphthalene 1-Fluoronaphthalene in isooctane Dapoxetine hydrochloride Impurity C Fluoronaphthalene, 10 mM in DMSO