1-Boc-헥사히드로-1,4-디아제핀
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1-Boc-헥사히드로-1,4-디아제핀 속성
- 녹는점
- 143.4 °C
- 끓는 점
- 95-110 °C0.5 mm Hg(lit.)
- 밀도
- 1.016 g/mL at 20 °C(lit.)
- 굴절률
- n
20/D 1.471(lit.)
- 인화점
- >230 °F
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 산도 계수 (pKa)
- 10.45±0.20(Predicted)
- 물리적 상태
- 액체
- Specific Gravity
- 1.016
- 색상
- 무색~황색
- 수용성
- 물에 섞이거나 혼합하기 어렵지 않습니다.
- 감도
- Air Sensitive
- BRN
- 7581789
- CAS 데이터베이스
- 112275-50-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
유엔번호(UN No.) | 2735 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 10-34 | ||
위험 참고 사항 | Irritant | ||
위험 등급 | IRRITANT, KEEP COLD | ||
위험 등급 | 8 | ||
HS 번호 | 29339900 |
1-Boc-헥사히드로-1,4-디아제핀 C화학적 특성, 용도, 생산
화학적 성질
Colorless to yellow liquid용도
1-Boc-hexahydro-1,4-diazepine is a diazepine derivative used in the preparation of pharmaceutical compounds such as histamine H3-receptor antagonists and dipeptidyl peptidase IV (DPP-IV) inhibitors.일반 설명
1-Boc-hexahydro-1,4-diazepine is an N-boc protected homopiperazine. Its enthalpy of vaporization at boiling point (558.15K) is 49.498kjoule/mol.Synthesis
To a solution of di-tert-butyldicarbonate (2.201 g, 9.780 mmol) in acetic acid (9.8 mL), a solution of 1,4-diazepane (1.0 g, 9.780 mmol) in acetic acid (9.8 mL) is added at room temperature. After 24 hours, water is added and the pH is adjusted to 10 using 10% NaOH. The aqueous phase is then extracted with dichloromethane (2 x 15 mL). The organic phase is dried and the solvent is evaporated to obtain tert-butyl 1,4-diazepane-1-carboxylate (1-Boc-hexahydro-1,4-diazepine) with a yield of 90.0%.주의 사항
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. It is sensitive to air.참고 문헌
Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. Bioorganic &Medicinal Chemistry. 2004, 12 (9), 2179-2191.Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents. Bioorganic & medicinal chemistry. 2013, 21 (7), 1628-1642.
1-Boc-헥사히드로-1,4-디아제핀 준비 용품 및 원자재
원자재
t-butyl chloroformate
아세트산 나트륨
에틸렌디아민
에틸알코올
메틸 T-뷰틸에테르
수산화칼륨
아세톤
황산 나트륨
톨루엔
디 -Tert- 부틸 디 카보네이트
브롬화트리에틸벤질암모늄
페놀
탄산 칼륨
나트륨
클로로포름
N,N'-비스(에틸렌)-p-톨루엔술폰아미드
아황산
1,3-디브로모프로판
파라-톨루엔설폰일 염화물
브롬화수소
디에틸에테르
호모피페라진
초산에틸
아미노디페닐메탄
염산
중탄산나트륨(중조)
아세트산(빙초산)
메틸알콜
수산화나트륨
테트라뷰틸암모늄 플루오린화물
n-부탄올
황산마그네슘
황산
준비 용품
1-Boc-헥사히드로-1,4-디아제핀 공급 업체
글로벌( 265)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9341 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10311 | 58 |
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 19479 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
1-Boc-헥사히드로-1,4-디아제핀 관련 검색:
시클로헵탄 호모피페라진
1-N-Boc-5-oxo-1,4-diazepane
1-Boc-hexahydro-1,4-diazepine
TETRT-BUTYL5-METHYL-1,4-DIAZEPANE-1-CARBOXYLATE
1-BOC-4-(CARBOXY-NAPHTHALEN-2-YL-METHYL)-[1,4]DIAZEPANE
1-BOC-4-(CARBOXY-THIOPHEN-3-YL-METHYL)-[1,4]DIAZEPANE
1-BOC-4-[CARBOXY-(1H-INDOL-2-YL)-METHYL]-[1,4]DIAZEPANE
4-(carboxy-p-tolyl-methyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester
1-BOC-4-(CARBOXY-PYRIDIN-3-YL-METHYL)-[1,4]DIAZEPANE
1-BOC-4-(BENZOFURAN-2-YL-CARBOXY-METHYL)-[1,4]DIAZEPANE
5-CYANO-2-[4-BUTOXYCARBONYL-1-(1,4-DIAZEPENYL)]-PYRIDINE
1-BOC-4-(CARBOXY-FURAN-2-YL-METHYL)-[1,4]DIAZEPANE
1-BOC-4-(CARBOXY-THIOPHEN-2-YL-METHYL)-[1,4]DIAZEPANE
di(tert-butyl) 1,4-diazepane-1,4-dicarboxylate
1-BOC-4-(CARBOXY-PYRIDIN-4-YL-METHYL)-[1,4]DIAZEPANE
BUTTPARK 75\08-55
TERT-BUTYL 4-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]-1,4-DIAZEPANE-1-CARBOXYLAT E