1-Bromo-2,3-difluorobenzene
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1-Bromo-2,3-difluorobenzene 속성
- 끓는 점
- 234 °C (765 mmHg)
- 밀도
- 1.724 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.509(lit.)
- 인화점
- 142 °F
- 저장 조건
- 2-8°C
- 물리적 상태
- 투명한 액체
- 색상
- 무색 내지 거의 무색
- Specific Gravity
- 1.724
- InChIKey
- RKWWASUTWAFKHA-UHFFFAOYSA-N
- CAS 데이터베이스
- 38573-88-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36/37/39-37/39 | ||
| 유엔번호(UN No.) | 1993 | ||
| WGK 독일 | 3 | ||
| 위험 참고 사항 | Flammable | ||
| 위험 등급 | 3.2 | ||
| 포장분류 | III | ||
| HS 번호 | 29039990 |
1-Bromo-2,3-difluorobenzene C화학적 특성, 용도, 생산
화학적 성질
Clear colorless to peach liquid용도
1-Bromo-2,3-difluorobenzene may be used in the synthesis of potent, orally active Calcitonin gene-related peptide (CGRP) receptor antagonist (BMS-846372). It may be used in the preparation of 2,3-difluorophenyl(dimethyl)phosphane.일반 설명
Microbial oxidation of 1-bromo-2,3-difluorobenzene by Pseudomonas putida strain 39/D and Escherichia coli recombinant microorganism (strain JM 109(pDTG601)) has been reported.Synthesis
Add 50% aqueous solution of KOH (18.0 g, 160 mmol) to a mixture of 1-bromo-5,5,6,6-tetrafluorocyclohex-1-ene (11.65 g) and triethylbenzylammonium chloride (0.15 g, 0.7 mmol) at 30-35°C for 30 minutes. Keep the reaction mixture at 75-85°C for 2 hours. Cool the reaction mixture. Dilute the reaction mixture with water. Extract the organic product with CH2Cl2. Dry the organic product over CaCl2. Distill the organic product. 1H NMR (CDCl3, 300.1 MHz), δ: 7.00-7.16 (m, 1H, Ar); 7.17-7.29 (m, 1H, Ar); 7.34-7.47 (m, 1H, Ar). 13C NMR (CDCl3, 75.5 MHz), δ: 110.40 (d, C(1), J = 17.5 Hz); 116.40 (d, C(4), J = 17.7 Hz); 124.70 (dd, C(5), J = 7.1 Hz, J = 5.0 Hz); 128.23 (d, C(6), J = 3.6 Hz); 148.10 (dd, C(2), J = 248.8 Hz, J = 14.3 Hz); 150.92 (dd, C(3), J = 251.9 Hz, J = 13.3 Hz). 19F NMR (CDCl3, 282.4 MHz), δ: -130.9 (m, 1 F, Ar), -134.8 (m, 1 F, Ar). BP 157-158°C. Elemental Analysis Found (%): C, 37.54; H, 1.50. C6H3BrF2. Calculated (%): C, 37.34; H, 1.52. Mass Spec MS, m/z (Irel (%)): 194, 192 [M]+ (100, 99), 113 [M-Br]+ (88), 63 (60).
Fig The synthetic method of 1-Bromo-2,3-difluorobenzene
저장
Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.1-Bromo-2,3-difluorobenzene 준비 용품 및 원자재
원자재
준비 용품
1-Bromo-2,3-difluorobenzene 공급 업체
글로벌( 418)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 |
wangxuhui1985@126.com | China | 57 | 55 |
| Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 |
sales@qinmuchem.com | China | 1009 | 58 |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 |
sales@kindchem.cn | China | 1226 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5893 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 997 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 |
justine@zhongda-biotech.com | China | 286 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20288 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18747 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 |
yuhh@hitechem.com | CHINA | 810 | 58 |
1-Bromo-2,3-difluorobenzene 관련 검색:
1-브로모-2,5-디플로로벤젠 1-브로모-2,3,5,6-테트라플로로벤젠 1-브로모-2,3,4-트리플로로벤젠 브로모펜타플로로벤젠 플루오린(불소) 1-브로모-2,6-디플로로벤젠 1-브로모-3,4-디플로로벤젠 1-브로모-3,5-디플로로벤젠 1-브로모-2,4-디플로로벤젠
4,4'-DIBROMOOCTAFLUOROBIPHENYL
1-Bromo-2,3-difluorobenzene
1,2-Dibromotetrafluorobenzene
1,4-DIBROMOTETRAFLUOROBENZENE
1-BROMO-2,3,6-TRIFLUOROBENZENE
4-BROMO-2,3,5,6-TETRAFLUOROBENZOTRIFLUORIDE
1-bromo-2,3,4,6-tetrafluorobenzene
1-Bromo-2,3,5-trifluorobenzene
1-BROMO-2,3,4,5-TETRAFLUOROBENZENE