1-Bromo-2,3-difluorobenzene
- CAS No.
- 38573-88-5
- Chemical Name:
- 1-Bromo-2,3-difluorobenzene
- Synonyms
- 2,3-DIFLUOROBROMOBENZENE;2,3-Diflurobromobenzene;2,3-DifluoroBrmorobenzene;1-Bromo-2,3-difL;1-Bromo-2,3-difluoro;Rimegepant Impurity 4;Rimegepant Impurity 33;2,3- twofluorine broMine;1-Bromo-2,3-difluobenzene;3-broMo-1,2-difluorobenzene
- CBNumber:
- CB8236717
- Molecular Formula:
- C6H3BrF2
- Molecular Weight:
- 192.99
- MDL Number:
- MFCD00061136
- MOL File:
- 38573-88-5.mol
- MSDS File:
- SDS
Boiling point | 234 °C (765 mmHg) |
---|---|
Density | 1.724 g/mL at 25 °C(lit.) |
refractive index |
n |
Flash point | 142 °F |
storage temp. | 2-8°C |
form | clear liquid |
color | Colorless to Almost colorless |
Specific Gravity | 1.724 |
InChIKey | RKWWASUTWAFKHA-UHFFFAOYSA-N |
CAS DataBase Reference | 38573-88-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
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Signal word | Warning | |||||||||
Hazard statements | H227-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338-P210e-P280a-P405-P501a-P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501 | |||||||||
Hazard Codes | Xi,F | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36/37/39-37/39 | |||||||||
RIDADR | 1993 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Flammable | |||||||||
HazardClass | 3.2 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29039990 | |||||||||
NFPA 704 |
|
1-Bromo-2,3-difluorobenzene price More Price(38)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | B1800 | 1-Bromo-2,3-difluorobenzene >98.0%(GC) | 38573-88-5 | 1g | $29 | 2024-03-01 | Buy |
TCI Chemical | B1800 | 1-Bromo-2,3-difluorobenzene >98.0%(GC) | 38573-88-5 | 5g | $55 | 2024-03-01 | Buy |
Alfa Aesar | B21585 | 1-Bromo-2,3-difluorobenzene, 98% | 38573-88-5 | 1g | $44.65 | 2024-03-01 | Buy |
Alfa Aesar | B21585 | 1-Bromo-2,3-difluorobenzene, 98% | 38573-88-5 | 5g | $132.65 | 2024-03-01 | Buy |
TCI Chemical | B1800 | 1-Bromo-2,3-difluorobenzene >98.0%(GC) | 38573-88-5 | 25g | $165 | 2024-03-01 | Buy |
1-Bromo-2,3-difluorobenzene Chemical Properties,Uses,Production
Chemical Properties
Clear colorless to peach liquid
Uses
1-Bromo-2,3-difluorobenzene may be used in the synthesis of potent, orally active Calcitonin gene-related peptide (CGRP) receptor antagonist (BMS-846372). It may be used in the preparation of 2,3-difluorophenyl(dimethyl)phosphane.
Uses
intermediate for liquid crystal and drugs
General Description
Microbial oxidation of 1-bromo-2,3-difluorobenzene by Pseudomonas putida strain 39/D and Escherichia coli recombinant microorganism (strain JM 109(pDTG601)) has been reported.
Synthesis
Add
50% aqueous solution of KOH (18.0 g, 160 mmol) to a mixture of
1-bromo-5,5,6,6-tetrafluorocyclohex-1-ene (11.65 g) and
triethylbenzylammonium chloride (0.15 g, 0.7 mmol) at 30-35°C for 30
minutes. Keep the reaction mixture at 75-85°C for 2 hours. Cool the
reaction mixture. Dilute the reaction mixture with water. Extract the
organic product with CH2Cl2. Dry the organic product over CaCl2. Distill the organic product. 1H NMR (CDCl3, 300.1 MHz), δ: 7.00-7.16 (m, 1H, Ar); 7.17-7.29 (m, 1H, Ar); 7.34-7.47 (m, 1H, Ar). 13C NMR (CDCl3,
75.5 MHz), δ: 110.40 (d, C(1), J = 17.5 Hz); 116.40 (d, C(4), J = 17.7
Hz); 124.70 (dd, C(5), J = 7.1 Hz, J = 5.0 Hz); 128.23 (d, C(6), J = 3.6
Hz); 148.10 (dd, C(2), J = 248.8 Hz, J = 14.3 Hz); 150.92 (dd, C(3), J =
251.9 Hz, J = 13.3 Hz). 19F NMR (CDCl3, 282.4 MHz), δ: -130.9 (m, 1 F, Ar), -134.8 (m, 1 F, Ar). BP 157-158°C. Elemental Analysis Found (%): C, 37.54; H, 1.50. C6H3BrF2. Calculated (%): C, 37.34; H, 1.52. Mass Spec MS, m/z (Irel (%)): 194, 192 [M]+ (100, 99), 113 [M-Br]+ (88), 63 (60).Fig The synthetic method of 1-Bromo-2,3-difluorobenzene
storage
Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.
1-Bromo-2,3-difluorobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | wangxuhui1985@126.com | China | 57 | 55 |
Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 | sales@qinmuchem.com | China | 1009 | 58 |
Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | sales@kindchem.cn | China | 1227 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
Related articles
- Synthesis and Application of 2,3-Difluorobromobenzene
- 2,3-Difluorobromobenzene is mainly used as a pharmaceutical intermediate.
- Oct 11,2022
View Lastest Price from 1-Bromo-2,3-difluorobenzene manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-19 | 1-Bromo-2,3-difluorobenzene
38573-88-5
|
US $10.00 / KG | 1KG | 99.% | 10 ton | Hebei Guanlang Biotechnology Co,.LTD | |
![]() |
2024-06-11 | 1-Bromo-2,3-difluorobenzene
38573-88-5
|
US $0.00-0.00 / kg | 1kg | 98% | 100 | Kindchem(Nanjing)Co.,Ltd | |
![]() |
2024-04-12 | 1-Bromo-2,3-difluorobenzene
38573-88-5
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd |
-
- 1-Bromo-2,3-difluorobenzene
38573-88-5
- US $10.00 / KG
- 99.%
- Hebei Guanlang Biotechnology Co,.LTD
-
- 1-Bromo-2,3-difluorobenzene
38573-88-5
- US $0.00-0.00 / kg
- 98%
- Kindchem(Nanjing)Co.,Ltd
-
- 1-Bromo-2,3-difluorobenzene
38573-88-5
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
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