ANTI-APAF-1

ANTI-APAF-1 C화학적 특성, 용도, 생산

용도

Anti-APAF1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

일반 설명

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. (provided by RefSeq)

Biochem/physiol Actions

Apoptotic protease activating factor 1 is a human homolog of C. elegans CED-4 gene and is a key regulator gene of apoptosis. It acts as a central component of the intrinsic pathway of apoptosis. Loss of APAF-1 expression is involved with chemorefractory malignant melanoma and neuronal cell differentiation. Over expression of this gene is related to an undifferentiated state in the testicular germ cell tumor (TGCT) pathway and is involved in carcinogenesis of germ cell tumors. APAF-1, when bound to cytochrome c, may trigger the activation of caspase-3 leading to apoptosis.

ANTI-APAF-1 준비 용품 및 원자재

원자재

준비 용품

ANTI-APAF-1 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Beinuo Biotechnology Co., Ltd.	--	beinuobio@163.com	CHINA	6580	58
Shanghai Yubo Biotechnology Co., Ltd.	--	shybio@126.com	CHINA	6969	58
Beijing Bai Ao Si Biotechnology Co., Ltd.	--	yangmei@bioneeds.net	CHINA	6999	58
Shenzhen Xinbosheng Biological Technology Co., Ltd.	--	service@neobioscience.com	CHINA	6164	58
Shanghai Hao Biological Technology Co., Ltd.	--	market@xlswkj.com	CHINA	6805	58
Shanghai Hao Biological Technology Co., Ltd.	--	shxiyuanbio@163.com	CHINA	6921	58
Shanghai Hao Zhun Biological Technology Co., Ltd.	--	info@zzsrm.com	CHINA	6846	58
Shanghai Zeye Biotechnology Co., Ltd.	--	shzeysw@163.com	CHINA	6550	58
Beijing Fubo Biotechnology Co., Ltd.	--	info@f-biology.com	CHINA	6039	58
Riedel-de Haen AG	--		United States	6825	87