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NFPA 704
0
2
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프로판산,3-[[[3-[2-(7-클로로-2-퀴놀리닐)에테닐]페닐][[3-(디메틸아미노)-3-옥소프로필]티오]메틸]티오]-,나트륨염,(이자형)- C화학적 특성, 용도, 생산
용도
MK-571 sodium salt hydrate has been used:
as an efflux inhibitor for monitoring multidrug resistance protein (MRP)-function and to avoid redundancy of other transporters
to assess its effect on cell proliferation and 2D-migration in vitro in various cell lines of glioblastoma multiforme (GBM)
as multidrug resistance (MDR) transporter inhibitor to study its effects in ovarian cancer cells
as specific inhibitors of ABCC1/2 to investigate transport, toxicity, flow cytometry and arsenic efflux
Biochem/physiol Actions
MK 571 is a potent and selective leukotriene D4 (LTD4) antagonist and ABCC multidrug resistance protein 1(MRP1) inhibitor. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, mediate their actions through two distinct G-protein coupled receptors. LTD4 is the preferred ligand for the CysLT1 receptor, whereas LTC4 and LTD4 bind with approximately equal affinity to the CysLT2 receptor. MK 571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK 571 effectively blocks LTD4 activation of recombinant human and mouse CysLT1 receptors but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors. It potentially inhibits MRP1 and has been shown to overcome acquired arsenic tolerance.
프로판산,3-[[[3-[2-(7-클로로-2-퀴놀리닐)에테닐]페닐][[3-(디메틸아미노)-3-옥소프로필]티오]메틸]티오]-,나트륨염,(이자형)- 준비 용품 및 원자재
원자재
준비 용품
프로판산,3-[[[3-[2-(7-클로로-2-퀴놀리닐)에테닐]페닐][[3-(디메틸아미노)-3-옥소프로필]티오]메틸]티오]-,나트륨염,(이자형)- 공급 업체
![프로판산,3-[[[3-[2-(7-클로로-2-퀴놀리닐)에테닐]페닐][[3-(디메틸아미노)-3-옥소프로필]티오]메틸]티오]-,나트륨염,(이자형)-](CAS/GIF/115103-85-0.gif)
