It is used in the production of pharma ingredients. It is a reagent in the synthesis of S-Methyl-N,N-diethylthiocarbamate Sulfoxide, which is an oxygenated metabolite of Disulfiram (Antabuse) that is capable of in vitro inactivation of liver mitochondrial aldehyde dehydrogenase.
Toxicology
The median
lethal dose (LD50) upon oral administration to
rats is about 200 mg/kg. The compound is
irritating to skin and eyes. The inhalation of an
atmosphere saturated with its vapors at 20℃ is
lethal to rats after 3 h. Diethylcarbamoyl
chloride has proved to be mutagenic on E. coli
strains in mutagenicity tests. It is weakly
mutagenic in high doses in the Ames test. In
view of these results and on account of the
structural similarity to dimethylcarbamoyl chloride, a carcinogenic potential cannot be ruled out.
The MAK commission has listed this substance
in group III B.
Safety Profile
Suspected carcinogen
with experimental carcinogenic data.
Moderately toxic by intraperitoneal route.
Mutation data reported. Reacts with water
or steam to produce toxic and corrosive
fumes. When heated to decomposition it
emits highly toxic fumes of Cl and NOx.
See also CARBATMATES and
CHLORIDES.
