Arbutamine Hydrochloride

Arbutamine Hydrochloride 구조식 이미지
카스 번호:
125251-66-3
상품명:
Arbutamine Hydrochloride
동의어(영문):
CBNumber:
CB83159851
분자식:
C18H24ClNO4
포뮬러 무게:
353.84
MOL 파일:
125251-66-3.mol

Arbutamine Hydrochloride 속성

녹는점
55-58°
알파
D23 -18.5° (in ethanol)

안전

Arbutamine Hydrochloride C화학적 특성, 용도, 생산

Originator

Genesa,Genesa,UK

Manufacturing Process

(R)-Arbutamin was produced as follows: 89.3 mg of (-)-1-di(tbutyldimethylsiloxy) phenyl)-2-aminoethanol, 50.0 mg of 4-(4- methoxymethoxyphenyl)butanoic acid, diethylphosphorylcyanide, and triethylamine were dissolved in N,N-dimethylformamide at 0°C, reacted at room temperature, so as to obtain 108.6 mg (in a yield of 82%) of amide compound. The amide compound obtained was reduced lithium aluminium hydride in an ether solvent at reflux temperature, so as to quantitative obtain amine. And 55.6 mg of (R)-arbutamin which is intended compound was obtained by deprotecting the hydroxyl-protecting group of amine in a methanol-THF solvent at room temperature using hydrochloric acid. [α]D 25 = -17 (c 1.15, EtOH).
(-)-1-(Dibutyldimethylsiloxy)phenyl)-2-aminoethanol was obtained by a hydrogenization of (R)-1-(3,4-di(t-butyldimethylsiloxyphenyl)-2-nitroethanol on 10% Pd/C.
The last compound was prepared as follows: the hydroxyl groups of 3,4- dihydroxy-benzaldehyde was protected using t-butyldimethylsilylchloride (1). 100 mg (0.26 mmol) of 3,4-di(t-butyl-methylsiloxy)benzaldehyde was dissolved in 1 ml tetrahydrofurane under atmosphere of argon at -40°C, and 0.30 ml of metal complex from (S)-6,6'-bis(triethylsilylethynyl)-1,1-dihydroxy- 2,2'-binaphtalene (2) mixed with a solution of n-butyllitium in hexane.After stirring for 30 minutes, 79.4 mg (1.3 mmol) of nitromethane was added dropwise to the mixture. After 67 hour reaction time, 2 ml of 1 N aqueous solution of hydrochloric acid added to stop the reaction. Product was extracted with 50 ml ethyl acetate, dehydrated with anhydrous sodium sulfate and concentrated within evaporator followed by silica gel chromatography (nhexane/ acetone = 10/1), after which (R)-1-(3,4-di(t-butyldimethylsiloxy) phenyl)-2-nitroethanol with an optical purity of 92% e.e. was obtained in a yield of 93%.

Therapeutic Function

Cardiotonic

Arbutamine Hydrochloride 준비 용품 및 원자재

원자재

준비 용품


Arbutamine Hydrochloride 공급 업체

글로벌( 3)공급 업체
공급자 전화 이메일 국가 제품 수 이점
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58
Pharmacodia (Beijing) Co.,Ltd +86-400-851-9921
sales@pharmacodia.com China 2317 55
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24017 58

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