피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P363
다시 사용전 오염된 의류는 세척하시오.
P405
밀봉하여 저장하시오.
NU7026 C화학적 특성, 용도, 생산
용도
NU7026 has been used:
as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells
생물학적 활성
ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC 50 values are 0.23, 13.0, > 100 and > 100 μ M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
Biochem/physiol Actions
Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).