디페록사민
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디페록사민 속성
- 녹는점
- 139°C
- 끓는 점
- 627.9°C (rough estimate)
- 밀도
- 1.2216 (rough estimate)
- 굴절률
- 1.5540 (estimate)
- 산도 계수 (pKa)
- 9.08±0.50(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
유해 물질 데이터 | 70-51-9(Hazardous Substances Data) | ||
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독성 | LD50 oral in mouse: 1340mg/kg |
그림문자(GHS): | |||||||||||||||||
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신호 어: | Warning | ||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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디페록사민 C화학적 특성, 용도, 생산
개요
Deferoxamine was introduced in the 1960s for chelation of iron. It is synthesized by removing a central iron molecule from ferrioxamine B, a compound obtained from the microorganism Streptomyces pilosus. Deferoxamine binds to iron from ferritin and forms ferrioxamine, a very stable and water-soluble chelate with a characteristic reddish color.용도
Deferoxamine is used for the treatment of both acute iron intoxication and chronic iron overload due to transfusiondependent anemias. It has also been used in trials for malaria treatment and for aluminum chelation in hemodialysis patients. Studies of a rat model of intracerebral hemorrhage have noted that deferoxamine treatment reduced oxidative stress from iron release, indicating a possible role in preventing damage associated with hemorrhagic strokes.환경귀착
Localized infusion or injection site reactions may occur with deferoxamine administration, such as pain, urticaria and flushing of the skin. Hypersensitivity reactions have been documented with both acute and chronic administration of deferoxamine. Some of the more serious side effects include infusion rate-related hypotension, renal insufficiency, neurotoxicity, growth retardation, pulmonary toxicity, and infections. Deferoxamine may induce venous dilation when given at doses greater than 15 mg kg-1 h-1 leading to poor venous return, depressed cardiac output, and eventually hypotension. Increased levels of histamine have been noted during hypotensive episodes, although pretreatment with antihistamines has not been shown to stop the reaction. An acute decrease in glomerular filtration rate and renal plasma flow secondary to hypotension is the possible mechanism underlying the nephrotoxicity induced by deferoxamine. Depletion of iron, translocation of copper, and chelation of other trace elements including zinc may interfere with critical iron-dependent enzymes, causing oxidative damage within various tissues. These are possible mechanisms thought to be responsible for deferoxamineinduced neurotoxicity, growth retardation, and pulmonary toxicity. In vitro studies have shown that deferoxamine inhibits the synthesis of prostaglandin, hemoglobin, ferritin, collagen, and DNA. The iron–deferoxamine complex, ferrioxamine, is a growth factor for many bacteria and fungi. Deferoxamine has been associated with Yersinia enterocolitica overgrowth and fatal cases of mucormycosis with prolonged therapy.디페록사민 준비 용품 및 원자재
원자재
디사이클로헥실카르보디이미디
나트륨 사이아노브로민하이드라이드(나트륨 시아노브롬하이드리드)
O-Benzylhydroxylamine hydrochloride
숙신산무수물
Palladium hydroxide
무수초산
Aluminium-nickel
6-디메틸아미노퓨린
4-[(5-{[(benzyloxy)carbonyl]amino}pentyl)(hydroxy)amino]-4-oxobutanoic acid
Butanoic acid, 4-[(4-cyanobutyl)(phenylmethoxy)amino]-4-oxo-
benzyl N-[5-(N-hydroxy-3-{[5-(N-hydroxy-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propanamido)pentyl]carbamoyl}propanamido)pentyl]carbamate
Butanediamide, N'-[5-[[4-[[5-[acetyl(phenylmethoxy)amino]pentyl]amino]-1,4-dioxobutyl](phenylmethoxy)amino]pentyl]-N-(4-cyanobutyl)-N-(phenylmethoxy)- (9CI)
(5-아미노펜틸)(페닐메톡시)카르밤산tert-부틸에스테르
benzyl 5-(3,6-dioxomorpholino)pentylcarbamate
벤질(5-(하이드록시아미노)펜틸)카바메이트
준비 용품
디페록사민 공급 업체
글로벌( 47)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 7726 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
PT CHEM GROUP LIMITED | |
peter68@ptchemgroup.com | China | 35426 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50003 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 |
orders@jknbiochem.com | China | 5225 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
디페록사민 관련 검색:
글리신 3-히드록시-1,2-디메틸-4(1H)-피리돈 펜토바르비탈 나트륨
ALTRENOGEST
Aminoferrocene
DEFEROXAMINE MESYLATE,DEFEROXAMINE METHANESULFONATE SALT,DEFEROXAMINE MESYLATE SALT
MAFA
Deferoxamine
AMINO ACIDS
Acetochlor+Atrazine (20%),penetrating emulsion
Deferoxamine Hydrochloride
hydroxyethyl starch-deferoxamine conjugate
dextran-deferoxamine
hydroxyethylstarch-deferoxamine
deferoxamine G1
gallium(67)-deferoxamine-dialdehyde starch-fibrinogen conjugate
deferoxamine-gamma-folate conjugate