This alkaloid is stereoisomeric with epiQuinine and occurs in 'Quinoidine', the
mixture of amorphous bases left after extraction of the four primary alkaloids of
Cinchona bark. It crystallizes in colourless leaflets from Et20 and is fluorescent
in dilute H2S04, It is dextrorotatory with [α]19D + 102.4° (c 0.8648, EtOH) and
furnishes a dihydrochloride, m.p. 195-6°C (dec.); [α]20D + 45.5° (c 0.8012,
EtOH); a hydrobromide, m.p. 240°C; thiocyanate, m.p. 193°C; [α]20D + 44.5°
(H20) and the dibenzoyl-(+)-tartrate, m.p. 167°C; [α]201D + 3.7° (c 0.8068,
EtOH-CHCI 3 ). Catalytic hydrogenation with Pd gives the dihydro derivative,
m.p. 122°C; [α]22D + 73.1° (c 0.766, EtOH).
용도
The 9-epimer of Quinidine (Q685000). Antimalarial.
