티카르실린-클라불란산

티카르실린-클라불란산 C화학적 특성, 용도, 생산

Antimicrobial activity

Activity is that of ticarcillin , the role of the inhibitor being to restore the activity against β-lactamase-producing strains that would otherwise hydrolyze the drug.

Pharmacokinetics

C_max 3 g ticarcillin + 100 mg: 330 mg/L end: 8 mg/L end
clavulanate intravenous: infusion: infusion
infusion (30 min)
Plasma half-life: 1.1 h 1.1 h
Plasma protein binding: 45% 25%
The pharmacokinetics of the two agents are mutually unaffected by co-administration. Ticarcillin can be detected in tissues and interstitial fluid following parenteral administration. Penetration into bile, peritoneal fluid and pleural fluid has been demonstrated. Concentrations in blister fluid were significantly lower than those in serum.
Around 60–70% of ticarcillin and 35–45% of clavulanic acid are excreted unchanged in urine during the first 6 h after administration of a single dose of the mixture.

Clinical Use

Septicemia, including bacteremia
Lower respiratory infections
Bone and joint infections
Skin and skin structure infections
Urinary tract infections (complicated and uncomplicated)
Gynecological infections, endometritis
Intra-abdominal infections, peritonitis
Its main use is in infections in which Ps. aeruginosa is suspected or proven.

부작용

Adverse reactions associated with ticarcillin occur . As with co-amoxiclav, there is a risk of cholestatic jaundice . Pseudomembranous colitis has been reported.

티카르실린-클라불란산 준비 용품 및 원자재

원자재

준비 용품

티카르실린-클라불란산 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
AILY INTL CHEMICAL CORP LTD	025-83208295 18913388297	ben@ailychem.com	China	131	50
Adamas Reagent, Ltd.	400-6009262 16621234537	chenyj@titansci.com	China	14113	59
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	16168	55
Chizhou Kailong Import and Export Trade Co., Ltd.		xg01_gj@163.com	China	9503	50
Hubei widely chemical technology Co., Ltd.	027-59402396 13419635609	13419635609@163.com	China	1982	55
Anhui kuer Bioengineering Co., Ltd	0551-65171243 13810511747	kuer@kuerhuaxue.com	China	2997	55
Hubei widely chemical technology Co., Ltd.	027-83778895 18602735115	18602735115@163.com	China	2000	64
Hefei Bomei Biotechnology Co., Ltd.	13856598764	531626407@qq.com	China	3008	58

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