1H-indazole-7-carboxylic acid
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1H-indazole-7-carboxylic acid 속성
- 녹는점
- ca 240℃
- 끓는 점
- 443.7±18.0 °C(Predicted)
- 밀도
- 1.506±0.06 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 3.71±0.10(Predicted)
- 색상
- 흰색에서 노란색으로
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 29339980 |
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1H-indazole-7-carboxylic acid C화학적 특성, 용도, 생산
용도
1H-indazole-7-carboxylic Acid is an inhibitor of nitric oxide synthases.제조 방법
Synthesis of 1H-indazole-7-carboxylic acid, H2L4: To 60 mL anhydrous toluene under a nitrogen atmosphere was added methyl-2-amino-3-methylbenzoate (1.8 g, 11 mmol) and KOAc (560 mg, 5.7 mmol), and the mixture heated to reflux, at which time acetic anhydride (3.2 mL, 34 mmol) was added and the mixture stirred at reflux for 10 min. Isoamyl nitrite (2.3 mL, 18 mmol) was added over 30 min and the mixture refluxed overnight. On cooling, the mixture was filtered and evaporated to dryness to give 1.6 g of a pale brown solid, which analysed for methyl 1H-indazole-7-carboxylate. This material was taken up in 40 mL THF, added to a solution of LiOH (5 g, 210 mmol) in 40 mL water, and heated at reflux for 48 h. On cooling, the mixture was concentrated on a rotary evaporator and the resulting aqueous phase filtered and adjusted to pH 4 with dilute HCl, to precipitate the product, which was filtered, washed with water and dried under vacuum. Yield 810 mg, 45%; mp 218–222 °C (decomp);δH (500 MHz, d6-DMSO): 7.23 (t, 1H, J = 7.5 Hz, H4 ), 7.97 (dd, 1H, J = 7.5, 1.0 Hz, H3 ), 8.06 (dd, 1H, J = 7.8, 0.8 Hz, H5 ), 8.21 (s, 1H, H2 ), 13.1 (br s, 2H, H1 & H6 ); δc (125 MHz, d6-DMSO): 113.7, 120.1, 124.6, 126.5, 129.0, 134.3, 138.0, 167.0; HRMS-ESI m/z: found: 163.0503; C8H7N2O2 requires: 163.0502 [M + H+ ]; ˉνmax/cm?1 (KBr): 3316 s br, 1700 s, 1619 m, 1592 m, 1509 m, 1285 s, 1201 m, 1145 m, 1078 m, 1056 w, 943 m, 858 s, 745 s, 638 m, 601 m.
1H-indazole-7-carboxylic acid 준비 용품 및 원자재
원자재
준비 용품
1H-indazole-7-carboxylic acid 공급 업체
글로벌( 252)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Taizhou Blazer Biomedical Technology Co., Ltd. | 0523-86112008 13915404123 |
sales@blazerbio.com | China | 88 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 |
act@arborchemical.com | CHINA | 906 | 58 |
TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 |
sales@tianpharm.com | CHINA | 304 | 58 |
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 19343 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
1H-indazole-7-carboxylic acid 관련 검색:
인다졸
1-[2,4-DICHLOROBENZYL]-1H-INDAZOLE-3-CARBOXYLIC ACID
1H-indazole-7-carboxylic acid
5-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID METHYL ESTER
INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER
1H-Indazole-3-carboxylic acid, 6-bromo-
5-Amino-1H-indazole-3-carboxylic acid methyl ester,1H-Indazole-3-carboxylic acid, 5-amino-, methyl ester
5-NITRO-1H-INDAZOLE-7-CARBOXYLIC ACID
3-FORMYL-7-INDAZOLE CARBOXYLIC ACID METHYL ESTER
5-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID
5-NITRO-1H-INDAZOLE-7-CARBOXYLIC ACID METHYL ESTER
6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID
5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER
7-METHOXYCARBONYL-1H-INDAZOLE-3-CARBOXYLIC ACID
1H-INDAZOLE-7-CARBOXYLIC ACID
ETHYL 1H-INDAZOLE-7-CARBOXYLATE
1-METHYL-1H-INDAZOLE-6-CARBOXYLIC ACID
7-ethyl-1H-indazole-3-carboxylic acid